We studied the effects of exogenous NO donor (sodium nitroprusside) and NO synthesis blocker (100 μM L-NAME) on baseline electrical activity of postganglionic fibers in the sympathetic superior cervical in rats during postnatal ontogeny. Starting the age of 20 days, sodium nitroprusside increased the mean discharge amplitude and the spectrum power in the respiratory (0.7-1.5 Hz) and cardiac (4-7 Hz) frequency bands. In contrast, application of L-NAME for 1 h decreased the spectrum power in these bands. Both agents produced no significant effect on the rhythmic sympathetic discharges at frequencies >8 Hz.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Masliukov PM, Nozdrachev AD. Rhythmical electrical activity in the cat stellate ganglion nerves during postnatal ontogenesis. Ros. Fiziol. Zh. 2006;92(3):324-329. Russian.
Sitdikova GF, Zefirov AL. Gaseous messengers in the nervous system. Ros. Fiziol. Zh. 2006;92(7):872-882.
Barman SM. What can we learn about neural control of the cardiovascular system by studying rhythms in sympathetic nerve activity? Int. J. Psychophysiol. 2016;103:69-78. Russian.
Copp SW, Hirai DM, Sims GE, Fels RJ, Musch TI, Poole DC, Kenney MJ. Neuronal nitric oxide synthase inhibition and regional sympathetic nerve discharge: Implications for peripheral vascular control. Respir. Physiol. Neurobiol. 2013;186(3):285-289.
Cossenza M, Socodato R, Portugal CC, Domith IC, Gladulich LF, Encarnação TG, Calaza KC, Mendonça HR, Campello-Costa P, Paes-de-Carvalho R. Nitric oxide in the nervous system: biochemical, developmental, and neurobiological aspects. Vitam. Horm. 2014;96:79-125.
Emanuilov AI, Korzina MB, Archakova LI, Novakovskaya SA, Nozdrachev AD, Masliukov PM. Development of the NADPHdiaphorase-positive neurons in the sympathetic ganglia. Ann. Anat. 2008;190(6):516-524.
Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur. Heart J. 2012;33(7):829-837.
Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol. Rev. 2010;90(2):513-557.
Masliukov PM. Discharge pattern of the sympathetic vertebral nerve activity in kittens in postnatal ontogenesis. Neurosci. Lett. 2003;344(2):141-143.
Masliukov PM, Fateev MM, Nozdrachev AD. Age-dependent changes of electrophysiologic characteristics of the stellate ganglion conducting pathways in kittens. Auton. Neurosci. 2000;83(1-2):12-18.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 136-139, February, 2019
Rights and permissions
About this article
Cite this article
Moiseev, K.Y., Verbovetskaya, A.I., Maslyukov, A.P. et al. Age-Dependent Effects of NO on Rhythmic Activity of Postganglionic Sympathetic Fibers. Bull Exp Biol Med 167, 191–193 (2019). https://doi.org/10.1007/s10517-019-04488-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04488-y