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Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium

Bulletin of Experimental Biology and Medicine volume 167, pages 43–46 (2019)Cite this article

We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces more selective cytotoxic effect on the stromal cells of the ectopic endometrium due to interaction with cannabinoid type 1 receptor. In concentrations below 1 μM, AA-DA stimulated the proliferation of stromal cells of the eutopic endometrium and did not affect the division of ectopic endometrium cells. This effect was realized due to its interaction with cannabinoid type 2 receptor.

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Authors and Affiliations

  1. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. M. Ashba, M. N. Yushina, I. A. Fedorova-Gogolina, A. G. Melkumyan, S. V. Pavlovich & M. Yu. Bobrov

  2. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    A. M. Ashba, N. M. Gretskaya, V. V. Bezuglov & M. Yu. Bobrov

Authors
  1. A. M. Ashba
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  2. M. N. Yushina
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  3. I. A. Fedorova-Gogolina
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  4. N. M. Gretskaya
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  5. V. V. Bezuglov
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  6. A. G. Melkumyan
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  7. S. V. Pavlovich
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  8. M. Yu. Bobrov
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Corresponding author

Correspondence to M. Yu. Bobrov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 1, pp. 46-50, January, 2019

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Ashba, A.M., Yushina, M.N., Fedorova-Gogolina, I.A. et al. Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium. Bull Exp Biol Med 167, 43–46 (2019). https://doi.org/10.1007/s10517-019-04456-6

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  • DOI: https://doi.org/10.1007/s10517-019-04456-6

Key Words

  • endometriosis
  • stromal cells
  • N-arachidonoyl dopamine
  • cytotoxicity
  • proliferation