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Analysis of the Serum Cytokine Profile in Allergic Patients Opens a Way to Personalized Treatment of Allergy

  • ALLERGOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Plant lipid transfer proteins and homologues of the main birch pollen allergen Bet v 1 are involved in the development of allergic reactions of varying severity to plant foods and pollen. In this study, the sera from patients with tree and weed pollen allergies in the Moscow region were examined. The levels of IL-4, IL-5, IL-9, IL-10, IL-13, IL-17A, IFNγ, TNFα, and TNFβ cytokines were determined in the sera of patients with specific IgE antibodies to Bet v 1 and Pru p 3 allergens. It was confirmed that patients with pollen allergy are often characterized by Th2 response of the immune system, though other mechanisms of allergy development occurred in some cases. The data obtained demonstrate the necessity of detailed analysis of the individual mechanism of allergic reactions and patient-centered approach to the personalized allergy treatment.

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Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    I. V. Bogdanov, E. I. Finkina, D. N. Melnikova, A. A. Tagaev & Т. V. Ovchinnikova

Authors
  1. I. V. Bogdanov
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  2. E. I. Finkina
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  3. D. N. Melnikova
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  4. A. A. Tagaev
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  5. Т. V. Ovchinnikova
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Corresponding author

Correspondence to Т. V. Ovchinnikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 736-740, December, 2018

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Bogdanov, I.V., Finkina, E.I., Melnikova, D.N. et al. Analysis of the Serum Cytokine Profile in Allergic Patients Opens a Way to Personalized Treatment of Allergy. Bull Exp Biol Med 166, 770–773 (2019). https://doi.org/10.1007/s10517-019-04437-9

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  • DOI: https://doi.org/10.1007/s10517-019-04437-9

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