Skip to main content

Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress

We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of “social” stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs. It was found that changes in the immune response caused by “social” stress are multidirectional, which confirms the theory of stress-induced “immune imbalance”. Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils. This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Akmayev IG. Neuroimmunoendocrinology, its Developmental Consideration. Uspekhi Fiziol. Nauk. 2003;34(4):4-15. Russian.

    Google Scholar 

  2. 2.

    Ashmarin IP, Koroleva SV. Regularities of interaction and functional continuum of neuropeptides (on the way to a unified concept).Vestn. Ross. Akad. Med. Nauk. 2002;(6):40-48. Russian.

  3. 3.

    Bukgakova OS. Immunity and various stages of stress reaction. Uspekhi Sovremen. Estestvoznaniya. 2011;(4):31-35. Russian.

  4. 4.

    Galimzyanov KM, Alieva AA, Burkin AV, Goreva ON. The dynamics of enzymatic activity of phagocytes in patients with chronic viral hepatitis c depending on the genotype. Astrakhan. Med. Zh. 2014;9(3):19-24. Russian.

    Google Scholar 

  5. 5.

    Dolotov OV, Andreeva LA, Novosadova EV, Myasoedov NF, Grivennikov IA, Eremin KO, Raevskii KS. Semax prevents the death of tyrosine hydroxylase-positive neurons in a mixed neuroglial cell culture derived from the embryonic rat mesencephalon in a model of 6-hydroxydopamine-induced neurotoxicity. Neurochem. J. 2015;9(4):295-298.

    Article  CAS  Google Scholar 

  6. 6.

    Karpenko SF, Galimzyanov HM. The slow type of hypersensitivity, the diagnostic and prognostic value of indicators of leukocyte migration activity. Astrakhan. Med. Zh. 2013;8(3):20-25Russian.

    Google Scholar 

  7. 7.

    Kasymova EB, Bashkina OA, Galimzyanov KhM. Peculiarities of the immune status and risk factors of the chronic course of Epstein-Barr viral infection in children. Novaya Nauka: Sovremen. Sostoyanie Puti Razvitiya. 2016;(8):16-20. Russian.

  8. 8.

    Kudryavtseva NN. Serotonergic control of aggressive behavior: new approaches - new interpretations (review) Zh. Vyssh. Nervn. Deyat. 2015;65(5):546. Russian.

    CAS  Google Scholar 

  9. 9.

    Manual for Preclinical Studies of New Pharmacological Substances. Part I, Mironov AN, ed. Moscow, 2012. Russian.

  10. 10.

    Titov VN. Biological function of stress, innate immunity, in flammatory reaction, and arterial hypertension. Klin. Lab. Diagn. 2008;(12):3-16Russian.

    Google Scholar 

  11. 11.

    Fedorova OV, Kraiushkina NG, Schefer EG, Fokina EN, Degtiar UV, Demidovich IL. Post-stress modulation of immunogenesis organs. Vestn. Volgograd. Gos. Med. Univer. 2010;(3):8-12. Russian.

  12. 12.

    Khavinson VKh, Kvetnoi IM, Ashmarin IP. Peptidergic regulation of homeostasis. Uspekhi Sovremen. Biol. 2002;122(2):190Russian.

    CAS  Google Scholar 

  13. 13.

    Khnychenko LK, Sapronov NS. Stress and its role in the development of pathological processes. Obzory Klin Farmakol. Lek. Ter. 2003;2(3):2-15Russian.

    Google Scholar 

  14. 14.

    Deak T, Quinn M, Cidlowski JA, Victoria NC, Murphy AZ, Sheridan JF. Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for stressrelated disease. Stress. 2015;18(4):367-380.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to A. L. Yasenyavskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 718-722, December, 2018

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Samotrueva, M.A., Yasenyavskaya, A.L., Murtalieva, V.K. et al. Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress. Bull Exp Biol Med 166, 754–758 (2019). https://doi.org/10.1007/s10517-019-04434-y

Download citation

Key Words

  • social stress
  • sensory contact
  • Semax
  • immune system