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Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress

We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of “social” stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs. It was found that changes in the immune response caused by “social” stress are multidirectional, which confirms the theory of stress-induced “immune imbalance”. Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils. This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.

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Correspondence to A. L. Yasenyavskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 718-722, December, 2018

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Samotrueva, M.A., Yasenyavskaya, A.L., Murtalieva, V.K. et al. Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress. Bull Exp Biol Med 166, 754–758 (2019).

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Key Words

  • social stress
  • sensory contact
  • Semax
  • immune system