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Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction

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Antithrombotic activity of a novel tricyclic derivative of diazepino[1,2-α]benzimidazole (DAB-15) was examined on the model of arterial thrombosis developed in rats without concomitant pathology and in rats with experimental myocardial infarction. DAB-15 demonstrated high antithrombotic efficacy in modeled thrombosis of carotid artery in rats without the concomitant pathology surpassing that of the reference drugs acetylsalicylic acid and clopidogrel by 5.1 and 4.8 times, respectively. In rats with experimental noncoronary myocardial infarction, DAB-15 increased the thrombus formation time by 86.2% in comparison with experimental control level in non-treated rats with similar myocardial infarction.

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Authors and Affiliations

  1. Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia

    A. A. Spasov, A. F. Kucheryavenko & V. S. Sirotenko

  2. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    V. A. Anisimova, L. N. Divaeva, T. A. Kuz’menko & A. S. Morkovnik

Authors
  1. A. A. Spasov
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  2. A. F. Kucheryavenko
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  3. V. S. Sirotenko
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  4. V. A. Anisimova
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  5. L. N. Divaeva
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  6. T. A. Kuz’menko
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  7. A. S. Morkovnik
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Corresponding author

Correspondence to A. F. Kucheryavenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 710-713, December, 2018

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Spasov, A.A., Kucheryavenko, A.F., Sirotenko, V.S. et al. Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction. Bull Exp Biol Med 166, 747–750 (2019). https://doi.org/10.1007/s10517-019-04432-0

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  • DOI: https://doi.org/10.1007/s10517-019-04432-0

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