We studied the effects of Ergoferon on the production of antiviral cytokine IL-2 by type 1 CD4+T cells. Preincubation of Jurkat cells with Ergoferon increased IL-2 secretion by these cells after stimulation with phorbol 12-myristate 13-acetate/ionomycine in comparison with the placebo group. The data prove that Ergoferon is capable of activating cell cascades involved in the realization of the antiviral immune response.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Geppe NA, Kondiurina EG, Galustyan AN, Pak TE, Baltserovich NB, Zhiglinskaya OV, Kamaev AV, Lazareva SG, Laleko SL, Melnikova IM, Perminova OA, Sabitov AU. Ergoferon Liquid Dosage Form — Efficacious and Safe Treatment for Childhood Acute Respiratory Infections. Interim Outcomes of a Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Antibiotiki Khimioterapiya. 2014;59(5-6):6-14. Russian.
Egorova VN, Babchenko IV, Degtyareva MV, Popovich AM. Interleukin-2: Clinical Application in the Pediatric Practice. St. Petersburg, 2008. Russian.
Emel’yanova AG, Grechenko VV, Petrova NV, Shilovskii IP, Gorbunov EA, Tarasov SA, Khaitov MR, Morozov SG, Epshtein OI. Effects of Release-Active Antibodies to CD4 Receptor on the Level of lck-Kinase in Cultured Mononuclear Cells from Human Peripheral Blood. Bull. Exp. Biol. Med. 2017;162(3):323-326.
Sergeeva IV, Kamzalakova NI, Tikhonova EP, Bulygin GV. Pathogenesis acute respiratory viral infections and influenza. Prakt. Med. 2012;(6):47-50Russian.
Kholodova IN, Zakharova IN, Ivakhnenko YI.1 Treatment of the complicated course ORI by means of natural origin. Med. Sovet. 2017;(1):82-86. Russian.
Shilovsky IP, Kornilaeva GV, Khaitov MR. Novel possibilities for the treatment of the respiratory-syncytial viral infection: the results of the preclinical study of Ergoferon. Immunologiya. 2012;33(3):144-148. Russian.
Shilovskiy IP, Prozorova MS, Khaitov MR. Investigation of ergoferon to suppress activity of respiratory syncytial virus in vitro. Immunologiya. 2015;36(4):216-219. Russian.
Bonilla FA, Oettgen HC. Adaptive immunity. J. Allergy. Clin. Immunol. 2010 Vol. 125(2, Suppl. 2):S33-S40.
Epstein O. The spatial homeostasis hypothesis. Symmetry. 2018;(4):103.
Hayashi K, Altman A. Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol. Res. 2007;55(6):537-544.
Phetsouphanh C, Kelleher AD. The role of PKC-θ in CD4+ T cells and HIV infection: to the nucleus and back again. Front. Immunol. 2015;6):391.
Rafalsky V, Averyanov A, Bart B, Minina E, Putilovskiy M, Andrianova E, Epstein O. Efficacy and safety of Ergoferon versus oseltamivir in adult outpatients with seasonal influenza virus infection: a multicenter, open-label, randomized trial. Int. J. Infect. Dis. 2016;51:47-55.
Smeets RL, Fleuren WW, He X, Vink PM, Wijnands F, Gorecka M, Klop H, Bauerschmidt S, Garritsen A, Koenen HJ, Joosten I, Boots AM, Alkema W. Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling. BMC Immunol. 2012;13:12. doi: https://doi.org/10.1186/1471-2172-13-12.
Strutt TM, McKinstry KK, Dibble JP, Winchell C, Kuang Y, Curtis JD, Huston G, Dutton RW, Swain SL. Memory CD4+ T cells induce innate responses independent of pathogen. Nat. Med. 2010;16(5):558-564.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 706-709, December, 2018
Rights and permissions
About this article
Cite this article
Kanareikina, M.A., Alinkina, E.S., Petrova, A.O. et al. Ergoferon Increases IL-2 Production by Activated Lymphocytes. Bull Exp Biol Med 166, 744–746 (2019). https://doi.org/10.1007/s10517-019-04431-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04431-1