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Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging

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The expression of Aβ42, and τ-protein, and p16 and p53 proteins was analyzed in the buccal epithelium of elderly and senile patients with Alzheimer’s disease. We revealed enhanced synthesis of Alzheimer’s disease markers Aβ42 (by 15-30 times) and τ-protein (by 5 times) in comparison with the corresponding values in people without neurodegenerative pathology of the same age groups. In addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. These data suggest that complex analysis of the expression of Aβ42, τ-protein, p16, and p53 in the buccal epithelium is a promising method for in vivo diagnosis of Alzheimer’s disease and assessment of the rate of aging during the development of this pathology.

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Authors and Affiliations

  1. St. Petersburg Research Center Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    V. A. Zuev, A. S. Dyatlova, N. S. Lin’kova & T. V. Kvetnaya

  2. Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia

    A. S. Dyatlova & N. S. Lin’kova

Authors
  1. V. A. Zuev
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  2. A. S. Dyatlova
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  3. N. S. Lin’kova
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  4. T. V. Kvetnaya
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Corresponding author

Correspondence to N. S. Lin’kova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 11, pp. 627-631, November, 2018

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Zuev, V.A., Dyatlova, A.S., Lin’kova, N.S. et al. Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging. Bull Exp Biol Med 166, 676–679 (2019). https://doi.org/10.1007/s10517-019-04416-0

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  • DOI: https://doi.org/10.1007/s10517-019-04416-0

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