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Cerebral Blood Flow in SHR Rats after Transplantation of Mesenchymal Stem Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Intracerebral transplantation of mesenchymal stem cells to 6- and 12-month-old SHR rats induced angiogenesis in the pia mater. In 6-months-old SHR rats, perfusion in the brain tissue after cell transplantation considerably increased, while in 12-month-old rats it remained practically unchanged. We also observed marked activation of regulatory processes in the cerebral vascular system, most pronounced in 12-month-old rats. Neurogenic and myogenic tone of cerebral vessels increased significantly, while endothelium-dependent tone slightly decreased. The increase in neurogenic and myogenic tone of blood vessels in SHR rats at the age of 6 and 12 months after transplantation of stem cells can be explained by the formation of new smooth muscle cells in the pre-existing arteries walls. Greater muscle mass developed stronger force and contributed to narrowing of the arterial lumen, as a result, there was no increase in blood flow despite the downstream angiogenesis. A slight decrease in endothelium-dependent tone can be explained by increased production of vasodilators by newly formed endothelial cells.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    I. B. Sokolova & G. I. Lobov

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  1. I. B. Sokolova
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  2. G. I. Lobov
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Correspondence to G. I. Lobov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 275-280, December, 2018

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Sokolova, I.B., Lobov, G.I. Cerebral Blood Flow in SHR Rats after Transplantation of Mesenchymal Stem Cells. Bull Exp Biol Med 166, 586–590 (2019). https://doi.org/10.1007/s10517-019-04396-1

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  • DOI: https://doi.org/10.1007/s10517-019-04396-1

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