Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 10, pp. 451-456, October, 2018
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Krylova, S.G., Povet’eva, T.N., Zueva, E.P. et al. Analgesic Activity of Hexaazaisowurtzitane Derivatives. Bull Exp Biol Med 166, 461–465 (2019). https://doi.org/10.1007/s10517-019-04372-9
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DOI: https://doi.org/10.1007/s10517-019-04372-9