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Prenatal Stimulation of 5-HT1A Receptors Improves Adaptive Behavior in Prenatally Stressed Rats

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Various types of adaptive behavior during the prepubertal period were analyzed in the offspring of rats receiving chronic injections of serotonin (5-HT) reuptake inhibitor fluoxetine, 5-HT1A receptor agonist buspirone, or their combination starting from gestation day 9 and subjected to immobilization stress from the 15th day of pregnancy until delivery. Prenatal stress increased pain sensitivity, prolonged inflammatory pain response, and increased the levels of anxiety and depression. Chronic administration of drugs acting through 5-HT1A receptors to pregnant rats improved the studied behavioral parameters in their offspring. Differences in the pain sensitivity were found between the effect of drug combination and each of them separately, and in the level of depression between combined administration and fluoxetine alone.

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Authors and Affiliations

  1. Laboratory of Ontogeny of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. A. Mikhailenko & I. P. Butkevich

  2. St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

    I. P. Butkevich

Authors
  1. V. A. Mikhailenko
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  2. I. P. Butkevich
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Correspondence to V. A. Mikhailenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 9, pp. 274-277, September, 2018

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Mikhailenko, V.A., Butkevich, I.P. Prenatal Stimulation of 5-HT1A Receptors Improves Adaptive Behavior in Prenatally Stressed Rats. Bull Exp Biol Med 166, 306–309 (2019). https://doi.org/10.1007/s10517-019-04338-x

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  • DOI: https://doi.org/10.1007/s10517-019-04338-x

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