Structural dynamics of the fibrous basis of the reparative regenerate during spontaneous skin wound healing comprises multiple stages, it successively transforms from one organization level to another more complex level, forms a multilevel 3D structure including molecular, supramolecular, fibrillar, fiber, and tissue elements. The formed reparative regenerate is integrated with the preserved skin, together they have common fibrous basis consisting of three parts that are different in organization of fibrous structures: atypical (central), tissue organospecific (peripheral), and transitional.
Similar content being viewed by others
References
Babaeva AG. Regeneration: Facts and Perspectives. Moscow, 2009. Russian.
Ivanishchuk PP, Kovalev AV. The effect of the liquid medium on the completeness of skin repair in rats. Morfologiya. 1993;105(11-12):78-81. Russian.
Canady J, Karrer S, Fleck M, Bosserhoff AK. Fibrosing connective tissue disorders of the skin: molecular similarities and distinctions. J. Dermatol. Sci. 2013;70(3):151-158.
Ehrlich HP, Hunt TK. Collagen organization critical role in wound contraction. Adv. Wound Care (New Rochelle). 2012;1(1):3-9.
Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci. Transl. Med. 2014;6(265):265sr6. doi: https://doi.org/10.1126/scitranslmed.3009337.
Erickson JR, Echeverri K. Learning from regeneration research organisms: the circuitous road to scar free wound healing. Dev. Biol. 2018;433(2):144-154.
Leavitt T, Hu MS, Marshall CD, Barnes LA, Lorenz HP, Longaker MT. Scarless wound healing: finding the right cells and signals. Cell Tissue Res. 2015;365(3):483-493.
Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Arch. Dermatol. Res. 2015;307(6):461-477.
Ud-Din S, Volk SW, Bayat A. Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives. Exp. Dermatol. 2014;23(9):615-624.
Walmsley GG, Maan ZN, Wong VW, Duscher D, Hu MS, Zielins ER, Wearda T, Muhonen E, McArdle A, Tevlin R, Atashroo DA, Senarath-Yapa K, Lorenz HP, Gurtner GC, Longaker MT. Scarless wound healing: chasing the holy grail. Plast. Reconstr. Surg. 2015;135(3):907-924.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 8, pp. 236-240, August, 2018
Rights and permissions
About this article
Cite this article
Omelyanenko, N.P., Mishina, E.S., Kovalev, A.V. et al. Structural Dynamics of the Fibrous Basis of Reparative Regenerate during Spontaneous Healing of the Skin Wound. Bull Exp Biol Med 166, 274–278 (2018). https://doi.org/10.1007/s10517-018-4331-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4331-3