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Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

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Bulletin of Experimental Biology and Medicine Aims and scope

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    E. A. Safonova, K. A. Lopatina, T. G. Razina, E. P. Zueva & E. P. Fedorova

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    A. M. Gur’ev & M. V. Belousov

Authors
  1. E. A. Safonova
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  2. K. A. Lopatina
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  3. T. G. Razina
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  4. E. P. Zueva
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  5. E. P. Fedorova
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  6. A. M. Gur’ev
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  7. M. V. Belousov
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Corresponding author

Correspondence to E. A. Safonova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 8, pp. 152-156, August, 2018

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Safonova, E.A., Lopatina, K.A., Razina, T.G. et al. Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.. Bull Exp Biol Med 166, 197–200 (2018). https://doi.org/10.1007/s10517-018-4313-5

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  • DOI: https://doi.org/10.1007/s10517-018-4313-5

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