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Aminoethane Sulfonic Acid Magnesium Salt Inhibits Ca2+ Entry Through NMDA Receptor Ion Channel In Vitro

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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of a cerebroprotective agent magnesium bis-aminoethanesulfonate (laboratory code FS-LKhT-317) on intracellular calcium concentration was studied by the fluorescent imaging technique on neuroglial cell culture from Spraque-Dawley rat hippocampus. The substance produced a pronounced inhibitory effect and suppressed NMDA receptor activity in concentrations of ≥50 μM. The observed effects were reversible or partially reversible and were detected by a decrease in Ca2+ signal amplitude in neurons in response to NMDA applications in a Mg2+-free medium and by inhibition of Ca2+ pulses in magnesium-free medium (elimination of magnesium block).

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Russia

    E. A. Turovsky, V. P. Zinchenko & M. E. Astashev

  2. N. P. Ogarev National Research Mordovian State University, Saransk, Russia

    E. V. Blinova, E. V. Semeleva, M. M. Geras’kina & I. A. Gromova

  3. Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna, Russia

    D. S. Blinov, S. Ya. Skachilova & A. B. Lebedev

Authors
  1. E. A. Turovsky
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  2. E. V. Blinova
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  3. E. V. Semeleva
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  4. V. P. Zinchenko
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  5. M. E. Astashev
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  6. D. S. Blinov
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  7. S. Ya. Skachilova
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  8. M. M. Geras’kina
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  9. A. B. Lebedev
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  10. I. A. Gromova
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Corresponding author

Correspondence to E. V. Blinova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 46-49, July, 2018

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Turovsky, E.A., Blinova, E.V., Semeleva, E.V. et al. Aminoethane Sulfonic Acid Magnesium Salt Inhibits Ca2+ Entry Through NMDA Receptor Ion Channel In Vitro. Bull Exp Biol Med 166, 39–42 (2018). https://doi.org/10.1007/s10517-018-4284-6

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  • DOI: https://doi.org/10.1007/s10517-018-4284-6

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