We propose an original model of atypical extremely extensive liver resection applicable for studying of the mechanisms of early and late hepatic and extrahepatic postoperative complications. After median laparotomy and mobilization of the middle and left lobes of the liver, 2-4 mattress sutures were applied to each lobe paracavally and 1 mm proximal to the proposed line of resection, the lobe parenchyma was cut off, and electrocoagulation of the wound surface was performed; the removed part was equivalent to 80% of the liver weight. This model of liver resection was used to study the pathogenetic factors of circulatory insufficiency in the postoperative period.
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Alientyev SA, Kotiv BN, Dzidzava II, Lazutkin MV, Molchanov AA. Chemotherapy in Surgical Treatment of the Colorectal Cancer Liver Metastases. Annaly Khir. Gepatol. 2010;15(4):9-17. Russian.
Anesthesiology. National Guideline. Bunatyan AA, Mizikov VM, eds. Moscow, 2011. Russian.
Belyakin SA, Tsarev MI, Rozhkov AG, Karandin VI, Philippov AV, Utlik YA, Dolgih RN, Nagaev RM. Experience of surgical treatment of patients with tumors of the liver, cancer of the gallbladder and proximal hepatic ducts. Vestn. Ross. Voen.-Med. Akad. 2010;(2):26-35. Russian.
Vishnevskii VA, Kubyshikin VA, Chzhao AV, Ikramov RZ. Liver Surgery. Guideline for Surgeons. Moscow, 2003. Russian.
Ermolaev PA, Khramykh TP, Barskaya LO. Coagulation abnormalities in early stage after maximally allowable liver resection in rats. Vestn. Ural. Med. Akad. Nauki. 2015;(4):56-59. Russian.
Ermolaev PA, Kramykh TP, Barskaya LO. Systemic Hemodynamic Changes after Maximally Allowable Liver Resection in Rats. Obshch. Reanimatologiya. 2015;11(1):14-21. Russian.
Ermolaev PA, Khramykh TP, Barskaya LO. Free Radical Oxidation in Rat Myocardium after Maximum Permissible Hepatic Resection. Bull. Exp. Biol. Med. 2016;160(5):625-627.
Ermolaev PA, Khramykh TP, Barskaya LO. Contractile function and myocardial metabolism in early period after maximally allowable liver resection in rats. Patol. Fiziol. Eksp. Ter. 2016;60(2):63-68. Russian.
Barskaya LO, Ermolaev PA, Khramykh TP, Poluektov VL. Patent Ru No. 2601160. Method of liver resection in small laboratory animals. Bull. No. 30. Published October 27, 2016.
Patuytko YuI, Polyakov AN, Sagaidak IV, Kotelnikov AG. The combined treatment of colorectal cancer with liver metastases. Khirurgiya. 2008;(7):20-24. Russian.
Patiutko IuI, Pylev AL, Ivanov AA, Kotel’nikov AG, Sagaĭdak IV, Podluzhnyĭ DV, Chuchuev ES, Abirov MA, Gakhramanov AD, Poliakov AN. Results of the repeated hepatic surgery on the reason of malignant tumors. Khirurgiya. 2012;(10):14-20. Russian.
Fedorov VD, Vishnevsky VA, Ikramov RZ. Main complications after major liver resections and possible ways of prevention. Byull. Sib. Med. 2007;6(3):16-21. Russian.
Aller MA, Lorente L, Prieto I, Moquillaza LM, Arias J. Hepatectomies in the rat: A look at the caudate process through microsurgery. Dig. Liver Dis. 2009;41(10):695-699.
López-Jiménez F, Paniagua D, Lamas GA. Interpretation of negative clinical trials. Rev. Invest. Clin. 1998;50(5):435-440.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 783-785, June, 2018
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Ermolaev, P.A., Khramykh, T.P. & Barskaya, L.O. Experimental Modeling of Atypical Extremely Extensive Liver Resection. Bull Exp Biol Med 165, 817–819 (2018). https://doi.org/10.1007/s10517-018-4272-x
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DOI: https://doi.org/10.1007/s10517-018-4272-x