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Changes in the Content of Mononuclear Liver Cells Expressing Immune Proteasomes after Transplantation of Ovarian Tissues Depending on Donor–Recipient Differences in Rats

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Implantation of ovarian tissue allografts in outbred Wistar rats and inbred August rats against the background of induction of donor-specific tolerance was accompanied by an increase in liver content of mononuclear cells expressing LMP2 immune of proteasome subunit by day 37 after transplantation in comparison with day 0. Graft rejection, on the contrary, was associated with a decrease in the number of LMP2+ cells in the liver of rats of both lines during this period. The difference in the content of these cells and the graft take rate were higher in Wistar rats. The number of mononuclear cells expressing LMP7 immune proteasome subunit in the liver did not change in rats of both lines by day 37 in comparison with day 0. Thus, the level of immune proteasomes with LMP2 subunit in mononuclear cells of the liver is related to fine mechanisms of regulation of immune responses and their shift toward graft take or rejection.

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References

  1. Bozhok GA, Alabedal’karim NM, Legach EI, Lyupina YV, Sharova NP, Karpova YD. Changes in the Expression of Immune Proteasomes in the Liver after the Induction of Portal Tolerance Depending on Donor—recipient Differences in Rats. Bull. Exp. Biol. Med. 2018;164(5):641-644.

    Article  CAS  Google Scholar 

  2. Karpova YaD, Bozhok GA, Lyupina YuV, Legach EI, Astakhova TM, Stepanova AA, Bondarenko TP, Sharova NP. Changes in proteasome function after induction of donorspecific tolerance in rats with allotransplantation of ovarian tissue. Izv. Ross. Aka. Nauk. Ser. Biol. 2012;(3):296-302. Russian.

    Google Scholar 

  3. Karpova YaD, Ustichenko VD, Alabedal’karim NM, Stepanova AA, Lyupina YuV, Boguslavski KI, Bozhok GA, Sharova NP. Change in the content of immunoproteasomes and macrophages in rat liver at the induction of donorspecific tolerance. Acta Naturae. 2017;9(3):71-80.

    PubMed  PubMed Central  Google Scholar 

  4. Stepanova AA, Karpova YaD, Lyupina YuV, Sharova NP, Bozhok GA, Ustichenko VD, Legach EI, Bondarenko TP, Vagida MS, Kazansky DB. Proteasomes on thyroid tissue allotransplantation under induction of donor-specific tolerance in rats. Russ. J. Bioorgan. Chem. 2014;40(1):36-47.

    Article  CAS  Google Scholar 

  5. Bedaiwy MA, El-Nashar SA, El Saman AM, Evers JL, Sandadi S, Desai N, Falcone T. Reproductive outcome after transplantation of ovarian tissue: a systematic review. Hum. Reprod. 2008;23(12):2709-2717.

    Article  Google Scholar 

  6. Fandrich F, Zhu X, Dresske B, Papachrysanthou A, Exner B, Chambers WH. Impact of RT1.C-encoded MHC antigens on host-versus-graft and graft versus-host reactions in a model of small bowel transplantation in the rat. Transplant Proc. 1997;29(3):1730-1731.

    Article  CAS  Google Scholar 

  7. Ferrington DA, Gregerson DS. Immunoproteasomes: structure, function, and antigen presentation. Prog. Mol. Biol. Transl. Sci. 2012;109:75-112.

    Article  CAS  Google Scholar 

  8. Johnson JD, Ao Z, Ao P, Li H, Dai LJ, He Z, Tee M, Potter KJ, Klimek AM, Meloche RM, Thompson DM, Verchere CB, Warnock GL. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant. 2009;(18)8:833-845.

    Article  Google Scholar 

  9. Kiroshka VV, Tishchenko YuO. Dynamics of folliculogenesis of sexually mature and neonatal ovarian tissue under conditions of long-term heterotopical transplantation. J. Evol. Biochem. Physiol. 2012;48(2):189-198.

    Article  CAS  Google Scholar 

  10. Knippels LM, Penninks AH, van Meeteren M, Houben GF. Humoral and cellular immune responses in different rat strains on oral exposure to ovalbumin. Food Chem. Toxicol. 1999;37(8):881-888.

    Article  CAS  Google Scholar 

  11. Marti HP, Henschkowski J, Laux G, Vogt B, Seiler C, Opelz G, Frey FJ. Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era. Transpl. Int. 2006;19(1):19-26.

    Article  CAS  Google Scholar 

  12. Panczak A, Bilá V, Sladká M, Krenová D, Otová B, Pravenec M, Kren V. Genetic analysis of graft-versus-host disease using rat recombinant inbred strains. Transplant Proc. 1997; 29(3): 1734-1735.

    Article  CAS  Google Scholar 

  13. Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J. Clin. Invest. 2004;114(10):1398-1403.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Science, Moscow, Russia

    Ya. D. Karpova, Yu. V. Lyupina & N. P. Sharova

  2. Institute of Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Kharkov, Ukraine

    N. M. Alabedal’karim, E. I. Legach & G. A. Bozhok

Authors
  1. Ya. D. Karpova
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  2. Yu. V. Lyupina
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  3. N. M. Alabedal’karim
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  4. E. I. Legach
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  5. G. A. Bozhok
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  6. N. P. Sharova
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Corresponding author

Correspondence to N. P. Sharova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 732-736, June, 2018

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Karpova, Y.D., Lyupina, Y.V., Alabedal’karim, N.M. et al. Changes in the Content of Mononuclear Liver Cells Expressing Immune Proteasomes after Transplantation of Ovarian Tissues Depending on Donor–Recipient Differences in Rats. Bull Exp Biol Med 165, 772–776 (2018). https://doi.org/10.1007/s10517-018-4263-y

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  • DOI: https://doi.org/10.1007/s10517-018-4263-y

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