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Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia, Moscow, Russia

    N. D. Bunyatyan

  2. National Pharmaceutical University, Kharkov, Ukraine

    E. A. Kal’ko, S. M. Drogovoz & A. V. Kononenko

Authors
  1. N. D. Bunyatyan
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  2. E. A. Kal’ko
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  3. S. M. Drogovoz
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  4. A. V. Kononenko
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Corresponding author

Correspondence to N. D. Bunyatyan.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 712-715, June, 2018

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Bunyatyan, N.D., Kal’ko, E.A., Drogovoz, S.M. et al. Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?. Bull Exp Biol Med 165, 754–757 (2018). https://doi.org/10.1007/s10517-018-4258-8

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  • DOI: https://doi.org/10.1007/s10517-018-4258-8

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