The time course of phospholipid composition of platelet plasma membranes at the peak of hemorrhagic shock were studied in rabbit experiments. The results indicate the key role of impairment of the structure of platelet membrane phospholipid bilayer in the pathogenesis of shockogenic thrombocytopathy.
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Kargapolov AV, Kartsova SV. A method for simultaneous fractionation of the main fractions of lysophospholipids and their diacyl derivatives. Vopr. Med. Khimii. 1975;21(3):325-327. Russian.
Kubatiev AA, Borovaya TG, Zhukhovitskii VG, Shevlyagina NV, Andreevskaya SG. Platelets: a modern view on the structure and function. Patogenez. 2016;14(1):4-13. Russian.
Shaturny VI, Shakhidzhanov SS, Sveshnikova AN, Panteleev MA. Activators, receptors and signal transduction pathways of blood platelets. Biomed. Khimiya. 2014;60(2):182-200. Russian.
Barber AJ, Jamieson GA. Isolation and characterization of plasma membranes from human blood platelets. J. Biol. Chem. 1970;245(23):6357-6565.
Brodde MF, Korporaal SJ, Herminghaus G, Fobker M, Van Berkel TJ, Tietge UJ, Robenek H, Van Eck M, Kehrel BE, Nofer JR. Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids. Atherosclerosis. 2011;215(2):374-382.
Heraud JM, Racaud-Sultan C, Gironcel D, Albigès-Rizo C, Giacomini T, Roques S, Martel V, Breton-Douillon M, Perret B, Chap H. Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4’,5’-bisphosphate are both required for ADP-dependent platelet spreading. J. Biol. Chem. 1998; 273(28):17,817-17,823.
Ibrahim S, Djimet-Baboun A, Pruneta-Deloche V, Calzada C, Lagarde M, Ponsin G. Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. Lipid Res. 2006;47(2):341-348.
Kasahara K, Kaneda M, Miki T, Iida K, Sekino-Suzuki N, Kawashima I, Suzuki H, Shimonaka M, Arai M, Ohno-Iwashita Y, Kojima S, Abe M, Kobayashi T, Okazaki T, Souri M, Ichinose A, Yamamoto N. Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts. Blood. 2013;122(19):3340-3348.
Koseoglu S, Meyer AF, Kim D, Meyer BM, Wang Y, Dalluge JJ, Haynes CL. Analytical characterization of the role of phospholipids in platelet adhesion and secretion. Anal. Chem. 2015;87(1):413–421.
Min SH, Abrams CS. Membrane grease eases platelet maturation. Blood. 2015;126(9):1055-1056.
Nofer JR, van Eck M. HDL scavenger receptor class B type I and platelet function. Curr. Opin. Lipidol. 2011;22(4):277-282.
Schaub LJ, Moore HB, Cap AP, Glaser JJ, Moore EE, Sheppard FR. Nonhuman primate model of polytraumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans. J. Trauma Acute Care Surg. 2017;82(3):461-469.
Sengupta T, Manoj N. Phosphatidylserine and phosphatidylethanolamine bind to protein Z cooperatively and with equal affinity. PLoS One. 2016;11(9):e0161896. doi: https://doi.org/10.1371/journal.pone.0161896.
Vanhaesebroeck B, Stephens L, Hawkins P. PI3K signalling: the path to discovery and understanding. Nat. Rev. Mol. Cell Biol. 2012;13(3):195-203.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 687-689, June, 2018
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Leskova, G.F. Phospholipid-Dependent Mechanisms of Platelet Dysfunction in Rabbits with Hemorrhagic Shock. Bull Exp Biol Med 165, 731–733 (2018). https://doi.org/10.1007/s10517-018-4253-0
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DOI: https://doi.org/10.1007/s10517-018-4253-0