Different levels of progressive convulsive readiness variously influence the dynamics of changes in heart rate variability parameters, inotropic and lusitropic reserves of the myocardium, which reflects the dependence of cardiac function on the level of convulsive readiness. Its increase is accompanied by a shift in autonomic balance towards potentiation of sympathetic influences on the heart, as well as a decrease in not only systolic, but also diastolic function, which reduces functional capacity of the heart and can lead to decompensation and prenosological state.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Karlov VA, Gnezditskiĭ VV, Depiaga IN, Gleĭzer MA. Epilepsy and the functional organization of the autonomic nervous system. Zh. Nevrol. Psikhiatr. 2013;113(8):4-9. Russian.
Basic & Clinical Pharmacology. Katzung BG, ed. Moscow, 2008. Russian.
Mamalyga ML, Mamalyga LM. The influence of growing seizure readiness on the autonomic regulation of the heart. Zh. Nevrol. Psikhiat. 2017;117(4):45-49. Russian.
Musina AM, Kalimullina LB. Frequency-temporal characteristics of peak-wave discharges on the EEG in rats with allelic differences in the structure of Gene receptor dopamine second type. Fundamental. Issled. 2010;(6):7-13. Russian.
Saidova MA. Dobutamine stress-echocardiography: possibility of clinical usage in cardiology practice. Rats. Farmakoter. Kardiol. 2009;5(4):73-79. Russian.
Aker RG, Onat FY. Cardiovascular regulation through hypothalamic GABA(A) receptors in a genetic absence epilepsy model in rat. Epilepsia. 2002;43(2):107-114.
Jansen K, Varon C, Huffel S, Lagae L. Cardiac and respiratory autonomic dysfunction in childhood epilepsy. Eur. J. Pediatric Neurol. 2013;17(1):29-38.
Mamalyga M.L. Cardiovascular Dysfunctions in Brain Disorders and Their Treatment. Saarbrücken, 2017.
Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP. Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav. 2013;26(3):375-385.
Onishi T, Tanaka H, Yamadori Y, Shigeru M, Matsumoto K, Fujiwara S, Kawai H, Hirata K. Left ventricular diastolic function is associated with cardiac sympathetic nerve activity in heart failure patients. Eur. Heart. J. 2013;34(Suppl. 1):182-183.
Picano Е. Stress Echocardiography. Heidelberg, 2009.
Ponnusamy A, Marques JL, Reuber M. Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures. Epilepsia. 2012;53(8):1314-1321.
Pradhan C, Sinha S, Thennarasu K, Jagadisha T. Quantitative analysis of heart rate variability in patients with absence epilepsy. Neurol. India. 2011;59(1):25-29.
Schuele SU, Widdess-Walsh P, Bermeo A, Lüders HO. Sudden unexplained death in epilepsy: the role of the heart. Cleve. Clin. J. Med. 2007;74(Suppl. 1):S121-S127.
Sicari R, Nihoyannopoulos P, Evangelista A, Kasprzak J, Lancellotti P, Poldermans D, Voigt JU, Zamorano JL; European Association of Echocardiography. Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur. J. Echocardiogr. 2008;9(4):415-437.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 6, pp. 669-675, June, 2018
Rights and permissions
About this article
Cite this article
Mamalyga, M.L., Mamalyga, L.M. Functional Capacity of the Heart in Progressive Convulsive Readiness. Bull Exp Biol Med 165, 715–720 (2018). https://doi.org/10.1007/s10517-018-4249-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4249-9