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Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia

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We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.

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Authors and Affiliations

  1. Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia

    I. E. Malysheva, L. V. Topchieva, O. V. Balan & I. V. Kurbatova

  2. Department of Hospital Therapy, Petrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia

    I. M. Marusenko & O. Yu. Barysheva

Authors
  1. I. E. Malysheva
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  2. L. V. Topchieva
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  3. O. V. Balan
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  4. I. M. Marusenko
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  5. O. Yu. Barysheva
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  6. I. V. Kurbatova
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Corresponding author

Correspondence to I. E. Malysheva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 620-623, May, 2018

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Malysheva, I.E., Topchieva, L.V., Balan, O.V. et al. Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia. Bull Exp Biol Med 165, 674–677 (2018). https://doi.org/10.1007/s10517-018-4239-y

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  • DOI: https://doi.org/10.1007/s10517-018-4239-y

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