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On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole)

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Original translational rat model of chronic heart failure provoked by experimental anterior transmural myocardium infarction was employed to examine the preventive action of anxiolytic Afobazole (15 mg/kg/day administered intraperitoneally during the first 15 days after coronary occlusion) on the development of the heart failure assessed in 3 months after infarction. Afobazole prevented the development of pathologic remodeling of the myocardium, maintained its inotropic function, and decreased the plasma level of brain natriuretic peptide known as a biochemical marker of chronic heart failure. In the myocardium, Afobazole down-regulated overexpression of the genes induced in chronic heart failure and assessed by corresponding RNA levels, which code angiotensin (AT1A-R), vasopressin (V1A-R), and glucocorticoid (GR) receptors as well as Epac2 protein. The revealed biochemical changes are consistent with the data on cardioprotective action of Afobazole.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences, Moscow, Russia

    S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. N. Stolyaruk, M. B. Vititnova, I. A. Miroshkina & S. B. Seredenin

  2. Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    L. M. Kozhevnikova & I. F. Sukhanova

Authors
  1. S. A. Kryzhanovskii
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  2. L. M. Kozhevnikova
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  3. I. B. Tsorin
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  4. I. F. Sukhanova
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  5. E. O. Ionova
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  6. V. N. Stolyaruk
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  7. M. B. Vititnova
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  8. I. A. Miroshkina
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  9. S. B. Seredenin
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Corresponding author

Correspondence to S. A. Kryzhanovskii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 605-609, May, 2018

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Kryzhanovskii, S.A., Kozhevnikova, L.M., Tsorin, I.B. et al. On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole). Bull Exp Biol Med 165, 660–664 (2018). https://doi.org/10.1007/s10517-018-4236-1

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  • DOI: https://doi.org/10.1007/s10517-018-4236-1

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