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Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver Transplantation

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Bulletin of Experimental Biology and Medicine Aims and scope

Transplantation of solid organs, including liver, induces a number of serious complications related to immune incompatibility and requiring long-term use of immunosuppressive drugs. Finding the ways to inducing recipient immunological tolerance to the grafts is a top priority in organ transplantation and immunology. Along with the search for immunosupressive therapy, the development of alternative approaches to induction of immunological tolerance based on cell technologies is now in progress. In this regard, studies of the so-called spontaneous operational tolerance observed in ~20% patients after orthotopic liver transplantation is a promising trend. Understanding of this phenomenon can shed light on the mechanisms of immunological tolerance to allografts and will help to identify specific tolerance biomarkers and cell types with the aptitude for the induction of tolerance to liver allografts.

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Authors and Affiliations

  1. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    I. V. Kholodenko, A. Yu. Lupatov & K. N. Yarygin

  2. M. M. She-myakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    R. V. Kholodenko

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Correspondence to I. V. Kholodenko.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 97-107, June, 2018

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Kholodenko, I.V., Kholodenko, R.V., Lupatov, A.Y. et al. Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver Transplantation. Bull Exp Biol Med 165, 554–563 (2018). https://doi.org/10.1007/s10517-018-4213-8

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  • DOI: https://doi.org/10.1007/s10517-018-4213-8

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