Using the model of cultured spinal ganglia, we demonstrated high neurotrophic activity of comenic acid and its derivatives potassium comenate and calcium comenate both under normal conditions and during oxidative stress. Calcium comenate in the norm as well as potassium and calcium comenates during oxidative stress demonstrate greater neurotrophic potency than comenic acid.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 4, pp. 457-462, April, 2018
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Shurygina, L.V., Zlishcheva, E.I. & Kravtsov, A.A. Neurotrophic Action of Comenic Acid and Its Derivatives Potassium Comenate and Calcium Comenate. Bull Exp Biol Med 165, 465–469 (2018). https://doi.org/10.1007/s10517-018-4195-6
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DOI: https://doi.org/10.1007/s10517-018-4195-6