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Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications

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Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1–7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p<0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1–7) attests to high predisposition of pregnant women to hypertension-related complications.

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References

  1. Belovol AN, Knyaz’kova II, Tsygankov AI. Sex-related peculiarities of the renin-angiotensin-aldosterone system: clinical significance in hypertension. Gendernaya Medicina 2014;(3-4):18-23. Russian.

  2. Krasnyi AM, Khlestova GV, Romanov AYu, Shchipitsyna VS, Bayev OR. Influence of magnesium therapy on ion homeostasis in women with preeclampsia. Vopr. Ginekol., Akush. Perinatol. 2016;15(6):12-16. Russian.

  3. Khlestova GV, Karapetyan AO, Shakaya MN, Romanov AYu, Baev OR. Maternal and perinatal outcomes in early and late preeclampsia. Akush. Gin. 2017;(6):41-47. Russian.

  4. Shuvalova MP, Frolova OG, Ratushnyak SS, Grebennik TK, Guseva EV. Preeclampsia and eclampsia as a cause of maternal death. Akush. Gin. 2014;(8):81-87. Russian.

  5. De Mello WC. Local renin angiotensin aldosterone systems and cardiovascular diseases. Med. Clin. North Am. 2017;101(1):117-127.

    Article  PubMed  Google Scholar 

  6. Gironacci MM. Angiotensin-(1-7): beyond its central effects on blood pressure. Ther. Adv. Cardiovasc. Dis. 2015;9(4):209-216.

    Article  PubMed  CAS  Google Scholar 

  7. Gromotowicz-Poplawska A, Szoka P, Kolodziejczyk P, Kramkowski K, Wojewodzka-Zelezniakowicz M, Chabielska E. New agents modulating the renin-angiotensin-aldosterone system — Will there be a new therapeutic option? Exp. Biol. Med. (Maywood). 2016;241(17):1888-1899.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Kızılırmak P, Üresin Y, Özdemir O, Kılıçkıran Avcı B, Tokgözoğlu L, Öngen Z. Renin-angiotensin-aldosterone system blockers and cardiovascular outcomes: a meta-analysis of randomized clinical trials. Turk. Kardiyol. Dern. Ars. 2017;45(1):49-66.

    PubMed  Google Scholar 

  9. Langer B, Grima M, Coquard C, Bader AM, Schlaeder G, Imbs JL. Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia. Obstet. Gynecol. 1998;91(2):196-202.

    Article  PubMed  CAS  Google Scholar 

  10. Paul M, Poyan Mehr A, Kreutz R. Physiology of local reninangiotensin systems. Physiol. Rev. 2006;86(3):747-803.

    Article  PubMed  CAS  Google Scholar 

  11. Roberts JM, Mascalzoni D, Ness RB, Poston L; Global Pregnancy Collaboration. Collaboration to understand complex diseases: preeclampsia and adverse pregnancy outcomes. Hypertension. 2016;67(4):681-687.

    Article  PubMed  CAS  Google Scholar 

  12. Santos RA, Ferreira AJ, Verano-Braga T, Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system. J. Endocrinol. 2013;216(2):R1-R17.

    Article  PubMed  CAS  Google Scholar 

  13. West CA, Sasser JM, Baylis C. The enigma of continual plasma volume expansion in pregnancy: critical role of the reninangiotensin-aldosterone system. Am. J. Physiol. Renal Physiol. 2016;311(6):F1125-F1134.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    G. V. Khlestova, A. Yu. Romanov, N. V. Nizyaeva, A. O. Karapetyan, O. R. Baev & T. Yu. Ivanets

  2. Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Faculty of Postgraduate Professional Education, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    O. R. Baev

Authors
  1. G. V. Khlestova
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  2. A. Yu. Romanov
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  3. N. V. Nizyaeva
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  4. A. O. Karapetyan
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  5. O. R. Baev
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  6. T. Yu. Ivanets
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Corresponding author

Correspondence to A. Yu. Romanov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 4, pp. 425-427, April, 2018

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Khlestova, G.V., Romanov, A.Y., Nizyaeva, N.V. et al. Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications. Bull Exp Biol Med 165, 438–439 (2018). https://doi.org/10.1007/s10517-018-4188-5

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  • DOI: https://doi.org/10.1007/s10517-018-4188-5

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