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Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

Cancer-testis antigens, effective markers of tissue malignant transformation, are characterized by heterogonous transcription depending on the pathological features of breast cancer. We performed screening of transcription profile of cancer-testis antigens specific for breast tumor tissues in female patients with and without regional metastasis. The relative expression of 16 genes (MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NY-ESO1, SSX2, SYCP1, and PRAME1) was analyzed by RT-qPCR method in biopsy specimens of the mammary gland tissues obtained during surgery from 25 patients. Differential transcription activity of cancer-testis antigens genes was observed in patients with metastatic (enhanced expression of MAGEA2, MAGEB1, and XAGE3 genes) and non-metastatic (enhanced expression of GAGE3 and PRAME1 genes) breast cancer.

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Authors and Affiliations

  1. Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia

    D. I. Vodolazhsky, D. S. Kutilin, Kh. A. Mogushkova & O. I. Kit

Authors
  1. D. I. Vodolazhsky
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  2. D. S. Kutilin
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  3. Kh. A. Mogushkova
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  4. O. I. Kit
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Correspondence to D. S. Kutilin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 3, pp. 360-363, March, 2018

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Vodolazhsky, D.I., Kutilin, D.S., Mogushkova, K.A. et al. Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer. Bull Exp Biol Med 165, 382–385 (2018). https://doi.org/10.1007/s10517-018-4175-x

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  • DOI: https://doi.org/10.1007/s10517-018-4175-x

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