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Transforming Growth Factor-β and Tumor Necrosis Factor-α Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells

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We studied the role of cytokines TGF-β and TNFα in reduction of the cytolytic activity of NK cells towards tumor cells. Exogenous TGF-β and TNFα reduced the sensitivity of MiaPaCa2 pancreatic adenocarcinoma cells to NK cytotoxicity, which was associated with reduction of ULBP-1 expression and increase of HLA-E, HLA-G, CD155, and CD112 expression on Mia-PaCa2 cells. Changes in the expression of ligands for NK receptors on tumor cells induced by TGF-β and TNFα may contribute to reduction of cytotoxicity of tumor-associated NK cells and thus prevent an adequate antitumor immune response leading to the disease progress.

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Authors and Affiliations

  1. Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan

    E. O. Ostapchuk, A. Kali & N. N. Belyaev

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  1. E. O. Ostapchuk
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  2. A. Kali
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  3. N. N. Belyaev
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Correspondence to E. O. Ostapchuk.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 2, pp. 224-228, February, 2018

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Ostapchuk, E.O., Kali, A. & Belyaev, N.N. Transforming Growth Factor-β and Tumor Necrosis Factor-α Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells. Bull Exp Biol Med 165, 259–263 (2018). https://doi.org/10.1007/s10517-018-4143-5

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  • DOI: https://doi.org/10.1007/s10517-018-4143-5

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