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Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats

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We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period. Fluoxetine reduced body weight in newborn females, but this parameter was restored to normal values by the age of 25 days. Fluoxetine also increased animal anxiety, but did not change the level of depressive behavior and cognitive capacities. It was shown that chronic injections of physiological solution to pregnant female enhanced nociceptive responses in the offspring during the prepubertal period, while fluoxetine neutralized the consequences of invasive intervention, which was expressed in a lower level of pain reaction in the offspring. This indicates the antinociceptive effect of fluoxetine.

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Authors and Affiliations

  1. Laboratory on Ontogenesis of Nervous System, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences, St. Petersburg, Russia

    I. P. Butkevich & V. A. Mikhailenko

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  1. I. P. Butkevich
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  2. V. A. Mikhailenko
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Correspondence to I. P. Butkevich.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 2, pp. 170-173, February, 2018

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Butkevich, I.P., Mikhailenko, V.A. Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats. Bull Exp Biol Med 165, 209–212 (2018). https://doi.org/10.1007/s10517-018-4131-9

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  • DOI: https://doi.org/10.1007/s10517-018-4131-9

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