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Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia

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The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.

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Authors and Affiliations

  1. Faculty of Fundamental Medicine, Moscow, Russia

    O. V. Povarova, V. S. Gusakov & O. S. Medvedev

  2. Medical Research and Educational Center, M. V. Lomonosov Moscow State University, Moscow, Russia

    A. V. Balatsky

Authors
  1. O. V. Povarova
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  2. A. V. Balatsky
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  3. V. S. Gusakov
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  4. O. S. Medvedev
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Corresponding author

Correspondence to O. V. Povarova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 80-83, January, 2018

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Povarova, O.V., Balatsky, A.V., Gusakov, V.S. et al. Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia. Bull Exp Biol Med 165, 69–71 (2018). https://doi.org/10.1007/s10517-018-4101-2

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  • DOI: https://doi.org/10.1007/s10517-018-4101-2

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