Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnitude, which suggests that that maturation of cholinergic structures involved in the regulation of cardiac activity is completed during the early postnatal ontogeny.
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References
Bursian AV. Structure of autorhythmical activity of contractile systems. J. Evol. Biochem. Physiol. 2012;48(2):219-235.
Kuznetsov SV, Goncharov NV, Glashkina LM. Change of parameters of functioning of the cardiovascular and respiratory systems in rats of different ages under effects of low doses of the cholinesterase inhibitor phosphacol. J. Evol. Biochem. Physiol. 2005;41(2):201-210.
Prozorovskii VB, Savateev NV. Non-Anticholinesterase Mechanisms of Action of Anticholinesterase Agents. Moscow, 1976. P. 26-37. Russian.
Timopheeva OP, Vdovichenko ND, Kuznetsov SV. Dynamics of the formation of rhythmic activity of the heart in fetuses and newborn rats. Bull. Exp. Biol. Med. 2012;152(4):397-401.
Khayutin VM, Lukoshkova EV. Fluctuations of heart rate: spectral analysis. Vestn. Aritmol. 2002;(26):10-21. Russian.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 52-56, January, 2018
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Sizonov, V.А., Dmitrieva, L.E. Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny. Bull Exp Biol Med 165, 44–47 (2018). https://doi.org/10.1007/s10517-018-4095-9
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DOI: https://doi.org/10.1007/s10517-018-4095-9