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Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.

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Authors and Affiliations

  1. Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia

    V. I. Apanasevich, N. G. Plekhova, A. V. Lagureva, A. V. Goncharov, E. A. Kotsyurbii, O. S. Plotnikova & D. A. Sivoraksha

  2. Far-Eastern Federal University, Ministry of Education and Science of the Russian Federation, Vladivostok, Russia

    O. V. Tarakova

  3. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science, Vladivostok, Russia

    V. I. Molchanova & P. A. Luk’yanov

Authors
  1. V. I. Apanasevich
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  2. N. G. Plekhova
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  3. A. V. Lagureva
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  4. A. V. Goncharov
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  5. E. A. Kotsyurbii
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  6. O. S. Plotnikova
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  7. D. A. Sivoraksha
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  8. O. V. Tarakova
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  9. V. I. Molchanova
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  10. P. A. Luk’yanov
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Corresponding author

Correspondence to A. V. Lagureva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 47-51, January, 2018

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Apanasevich, V.I., Plekhova, N.G., Lagureva, A.V. et al. Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia. Bull Exp Biol Med 165, 40–43 (2018). https://doi.org/10.1007/s10517-018-4094-x

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  • DOI: https://doi.org/10.1007/s10517-018-4094-x

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