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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 6, pp 766–769 | Cite as

Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals

  • N. N. Drozd
  • M. A. Torlopov
  • E. V. Udoratina
  • Yu. S. Logvinova
BIOTECHNOLOGIES

Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.

Key Words

chitin nanoparticles plasma/blood clotting 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. N. Drozd
    • 1
  • M. A. Torlopov
    • 2
  • E. V. Udoratina
    • 2
  • Yu. S. Logvinova
    • 1
  1. 1.Hematology Research CenterMinistry of Health of the Russian FederationMoscowRussia
  2. 2.Institute of Chemistry of Komi Research CenterUral Division of Russian Academy of ScienceSyktyvkarRussia

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