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Changes in Activity of Matrix Metalloproteinases and Serum Concentrations of Proinsulin and C-Peptide Depending on the Compensation Stage of Type 2 Diabetes Mellitus

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

In patients with type 2 diabetes mellitus, serum activities of MMP-2 and MMP-7 were substantially decreased in comparison with apparently healthy individuals. At the decompensation stage, along with the increased content of glucose and glycated hemoglobin, a pronounced (3-fold) increase in proinsulin concentration was observed. On the contrary, MMP activity and C-peptide concentration decreased at this stage. The ratio of proinsulin concentration to MMP activity at the stages of diabetes mellitus compensation and subcompensation was approximately 1:50, while at the stage of decompensation it was 1:12. Thus, the ratio of these blood serum parameters can be used as an additional diagnostic marker of diabetes decompensation and severity of its complications.

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References

  1. Bondar’ IA, Klimontov VV. The role of matrix metalloproteinases and their inhibitors in the development of renal fibrosis in the patients with diabetes mellitus. Probl. Endokrinol. 2012;58(1):39-44. Russian.

    Article  Google Scholar 

  2. Poteryaeva ON, Russkich GS, Panin LE. Analysis of serum activities of matrix metalloproteinases and α1-proteinase inhibitor in patients with type 2 diabetes mellitus. Bull. Exp. Biol. Med. 2012;152(5):578-579.

    Article  CAS  PubMed  Google Scholar 

  3. Poteryaeva ON, Russkikh GS, Chernysheva AS, Mokrushnikov PV. Method for martix proteinas action determination in blood serum. J. Sib. Med. Sci. 2010;(6). [URL: http://ngmu.ru/cozo/mos/article/text_full.php? id=461].

  4. EASD/ESC recommendations for diabetes, pre-diabetes and cardiovascular diseases. Ross. Kardiol. Zh. 2014;(3):7-61. Russian.

  5. Khasigov PZ, Ktsoeva SA, Gatagonova TM, Grachev SV, Tareeva IE, Grachev SV, Berezov TT. The role of matrix metalloproteinases in the development of diabetic nephropathy. Biokhimiya. 2000;65(5):613-619. Russian.

    Google Scholar 

  6. Anderson SS, Wu K, Nagase H, Stettler-Stevenson WG, Kim Y, Tsilibary EC. Effect of matrix glycation on expression of type IV collagen, MMP-2, MMP-9 and TIMP-1 by human mesangial cells. Cell. Adhes. Commun. 1996;4(2):89-101.

    Article  CAS  PubMed  Google Scholar 

  7. Ban CR, Twigg SM, Franjic B, Brooks BA, Celermajer D, Yue DK, McLennan SV. Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Res. Clin. Pract. 2010;87(3):335-341.

    Article  CAS  PubMed  Google Scholar 

  8. Ebihara I, Nakamura T, Shimada N, Koide H. Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus. Am. J. Kidney Dis. 1998;32(4):544-550.

    Article  CAS  PubMed  Google Scholar 

  9. Lan CC, Liu IH, Fang AH, Wen CH, Wu CS. Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetes. Br. J. Dermatol. 2008;159(5):1103-1115.

    CAS  PubMed  Google Scholar 

  10. McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE. Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int. 2007;72(4):481-488.

    Article  CAS  PubMed  Google Scholar 

  11. Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005;54(3):694-701.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Rysz J, Banach M, Stolarek RA, Pasnik J, Cialkowska-Rysz A, Koktysz R, Piechota M, Baj Z. Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy. J. Nephrol. 2007;20(4):444-452.

    CAS  PubMed  Google Scholar 

  13. Thrailkill KM, Clay Bunn R, Fowlkes JL. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocrine. 2009;35(1):1-10.

    Article  CAS  PubMed  Google Scholar 

  14. Wang J, Li Y, Xu M, Li D, Wang Y, Qi J, He K. C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells. Exp. Ther. Med. 2016;12(6):4142-4146.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Biochemistry, Novosibirsk, Russia

    O. N. Poteryaeva, G. S. Russkikh, A. V. Zubova & I. F. Usynin

  2. Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

    M. M. Gevorgyan

Authors
  1. O. N. Poteryaeva
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  2. G. S. Russkikh
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  3. A. V. Zubova
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  4. M. M. Gevorgyan
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  5. I. F. Usynin
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Corresponding author

Correspondence to O. N. Poteryaeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 12, pp. 697-700, December, 2017

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Poteryaeva, O.N., Russkikh, G.S., Zubova, A.V. et al. Changes in Activity of Matrix Metalloproteinases and Serum Concentrations of Proinsulin and C-Peptide Depending on the Compensation Stage of Type 2 Diabetes Mellitus. Bull Exp Biol Med 164, 730–733 (2018). https://doi.org/10.1007/s10517-018-4068-z

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  • DOI: https://doi.org/10.1007/s10517-018-4068-z

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