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Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Mature normotensive male WAG rats and stress-sensitive hypertensive ISIAH rats were exposed to “everyday life stress” modelled by alternation of immobilization and adaptation. Increased LPO intensity (increased content of substrates with unsaturated double bonds and primary and secondary LPO products) and reduced content of some antioxidant protection components (reduced retinol level and GSH/GSSG ratio) were revealed in the blood of ISIAH rats. These changes correlated with elevated mean BP. The results can reflect the significant role of LPO changes in the pathogenesis of stress-induced arterial hypertension.

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References

  1. Volchegorskii IA, Dolgushin II, Kolesnikov OL, Tseilikman VE. Experimental Modeling and Laboratory Assessment of Adaptive Reactions of the Organism. Chelyabinsk, 2000. Russian.

  2. Kamyshnikov VS. Handbook on Clinical and Biochemical Studies and Laboratory Diagnostics. Moscow, 2009. Russian.

  3. Kolesnikova LI, Grebyenkina LA, Dolgikh VV, Natyaganova LV, Osipova YeV, Starostenko OV. The assessment of processes of lipoperoxidation in adolescents with essential arterial hypertension using the integral indicator. Klin. Lab. Diagnost. 2012;(6):29-31. Russian.

  4. Kolesnikova LI, Darenskaya MA, Grebenkina LA, Labygina AV, Suturina LV, Dolgikh M, Shipkhineeva TI, Darzhaev ZYu, Tsyrenov TB,, Rinchindorzhieva MP. Characteristics of lipoperoxidation processes in women of different populations with hyperprolactinemia and infertility. Zh. Akush. Zhen. Bol. 2011;LX(5):55-61. Russian.

    Google Scholar 

  5. Kolesnikova LI, Suturina LV, Labygina AV, Osipova EV, Leshenko OY, Zagarskich EU, Fedorov BA, Dolgih MI, Sholohov LF, Petrova VA, Nadeliaeva JG, Atalyan AV, Lazareva LM, Kornakova NV, Darenskaia MA. Reproductive status, lipid peroxidation and antioxidation system in teenagers, living in large industrial center Angarsk. Acta Biomedica Scientifica. 2005;(5):42-47. Russian.

    Google Scholar 

  6. Petrovskaya AS, Krivoshapkin AL, Aftanas LI, Krivoshapkin AL. Electrophysiological studies and tactics of treatment of patients with trigeminal neuralgia. Sib. Nauch. Med. Zh. 2013;33(3):5-11. Russian.

    Google Scholar 

  7. Pivovarova ЕN, Dushkin МI, Perepechaeva ML, Коbzev VF, Тrufakin VА, Маrkel АL. All signs of metabolic syndrome in the hypertensive isiah rats are associated with increased activity of transcription factors PPAR, LXR, PXR, and CAR in the liver. Biomed. Khimiya. 2011;57(4):435-445. Russian.

    Article  CAS  Google Scholar 

  8. Redina OE, Klimov LO, Ershov NI, Abramova TO, Ivanova LN, Markel AL. The downregulation of genes controlling vascular tone in kidneys of isiah rats with stress-induced arterial hypertension. Vavilov. Zh. Genetiki Selektsii. 2014;18(4-2):910-919. Russian.

  9. Manual on Experimental (Preclinical) Study of New Pharmacological Substances, Khabriev RU, ed. Moscow, 2005. Russian.

  10. Tseilikman VE, Tseilikman OB, Sinitskii AI, Lavin EA, Lapteva IA, Gornostaeva AB, Borisenkov AV, Nusratov MI, Romanov DA. Biochemical strategies of adaptation under conditions of chronic stress. Chelovek. Sport. Meditsina. 2008;(4):56-57. Russian.

  11. Essential Hypertension and Genes of the Renin—Angiotensin System. Kolesnikova LI, ed. Novosibirsk, 2008. Russian.

  12. ISIAH RAT Database. [URL: http://icg.nsc.ru/isiah/].

  13. Kolesnikova LI, Semyonova NV, Grebenkina LA, Darenskaya MA, Suturina LV, Gnusina SV. Integral indicator of oxidative stress in human blood. Bull. Exp. Biol. Med. 2014;157(6):715-717.

    Article  CAS  PubMed  Google Scholar 

  14. Novozhilov AV, Tavrovskaya TV, Ivanov VA, Morozov VI. Hematological parameters and redox balance of rat blood in the dynamics of immobilization. Bull. Exp. Biol. Med. 2013;155(4):447-450.

    Article  CAS  PubMed  Google Scholar 

  15. Volchegorskii IA, Tseilikman VE, Ship SA, Bubnov NV, Sinitskii AI. The effects of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats. Neurosci. Behav. Physiol. 2003;33(6):595-599.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Center of Family Health and Human Reproduction, Irkutsk, Russia

    L. I. Kolesnikova, L. V. Rychkova, L. R. Kolesnikova, M. A. Darenskaya, L. V. Natyaganova, L. A. Grebenkina & S. I. Kolesnikov

  2. Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia

    L. R. Kolesnikova & L. I. Korytov

  3. M. V. Lomonosov Moscow State University, Moscow, Russia

    S. I. Kolesnikov

Authors
  1. L. I. Kolesnikova
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  2. L. V. Rychkova
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  3. L. R. Kolesnikova
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  4. M. A. Darenskaya
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  5. L. V. Natyaganova
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  6. L. A. Grebenkina
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  7. L. I. Korytov
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  8. S. I. Kolesnikov
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Corresponding author

Correspondence to M. A. Darenskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 12, pp. 677-680, December, 2017

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Kolesnikova, L.I., Rychkova, L.V., Kolesnikova, L.R. et al. Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress. Bull Exp Biol Med 164, 712–715 (2018). https://doi.org/10.1007/s10517-018-4064-3

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  • DOI: https://doi.org/10.1007/s10517-018-4064-3

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