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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 6, pp 712–715 | Cite as

Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress

  • L. I. Kolesnikova
  • L. V. Rychkova
  • L. R. Kolesnikova
  • M. A. Darenskaya
  • L. V. Natyaganova
  • L. A. Grebenkina
  • L. I. Korytov
  • S. I. Kolesnikov
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY

Mature normotensive male WAG rats and stress-sensitive hypertensive ISIAH rats were exposed to “everyday life stress” modelled by alternation of immobilization and adaptation. Increased LPO intensity (increased content of substrates with unsaturated double bonds and primary and secondary LPO products) and reduced content of some antioxidant protection components (reduced retinol level and GSH/GSSG ratio) were revealed in the blood of ISIAH rats. These changes correlated with elevated mean BP. The results can reflect the significant role of LPO changes in the pathogenesis of stress-induced arterial hypertension.

Key Words

arterial hypertension oxidative stress antioxidants arterial blood pressure immobilization stress 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • L. I. Kolesnikova
    • 1
  • L. V. Rychkova
    • 1
  • L. R. Kolesnikova
    • 1
    • 2
  • M. A. Darenskaya
    • 1
  • L. V. Natyaganova
    • 1
  • L. A. Grebenkina
    • 1
  • L. I. Korytov
    • 2
  • S. I. Kolesnikov
    • 1
    • 3
  1. 1.Research Center of Family Health and Human ReproductionIrkutskRussia
  2. 2.Irkutsk State Medical UniversityMinistry of Health of the Russian FederationIrkutskRussia
  3. 3.M. V. Lomonosov Moscow State UniversityMoscowRussia

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