Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 680–684 | Cite as

Microscopic Study of Nervous System Plasticity: Interactions of Sympathetic Nerves with Neurons of Intraocular Hippocampal Transplants

  • Z. N. Zhuravleva
  • E. A. Mugantseva
  • G. I. Zhuravlev

Functional interactions of sympathetic fibers innervating the iris with the neurons of central origin in intraocular transplants of the rat hippocampus were studied by optic, confocal, and electron microscopy. After formaldehyde fixation, fluorescent dye Dil was applied to the upper cervical ganglion; the dye migrated to the transplant by lateral diffusion via axons. Sympathetic nerves labeled with fluorescent dye grew into the neurotransplants along perivascular membranes of blood vessels. In addition, some fluorescent axons were identified in the transplant parenchyma. Electron microscopy showed large bundles of the peripheral type axons in the vascular adventitia and Schwann-axonal complexes in the transplant neuropil. Autonomic axons formed synaptic contacts with transplanted neurons.

Key Words

intraocular neurotransplants hippocampus autonomic sympathetic nervous system synaptic contacts 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Z. N. Zhuravleva
    • 1
  • E. A. Mugantseva
    • 1
  • G. I. Zhuravlev
    • 2
  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Cell BiophysicsMoscow RegionRussia

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