Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 676–679 | Cite as

Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors

  • A. V. Shubin
  • E. A. Lesovaya
  • K. I. Kirsanov
  • E. E. Antoshina
  • L. S. Trukhanova
  • T. G. Gorkova
  • G. A. Belitsky
  • M. G. Yakubovskaya
  • I. V. Demidyuk
Article
  • 6 Downloads

Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these models is esophageal cancer induction in rats by N-nitroso compound precursors. Despite adequate reproduction of human esophageal cancer, this model in fact has not been used since the 1990ies. Re-examination of esophageal cancer model, induced by N-nitrososarcosine ethyl ester precursors, is carried out and its efficiency in induction of squamous cell carcinoma is confirmed.

Key Words

esophageal cancer model N-nitrosocompounds N-nitrososarcosine precursors 

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References

  1. 1.
    Alexandrov VA, Novikov AI, Zabezhinsky MA, Stolyarov VI, Petrov AS. The stimulating effect of acetic acid, alcohol and thermal burn injury on esophagus and forestomach carcinogenesis induced by N-nitrososarcosine ethyl ester in rats. Cancer Lett. 1989;47(3):179-185.CrossRefPubMedGoogle Scholar
  2. 2.
    Balansky RM, Ganchev G, D’Agostini F, De Flora S. Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate. Int. J. Cancer. 2002;98(4):493-497.CrossRefPubMedGoogle Scholar
  3. 3.
    Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, 2013.Google Scholar
  4. 4.
    Morse MA, Kresty LA, Steele VE, Kelloff GJ, Boone CW, Balentine DA, Harbowy ME, Stoner GD. Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. Nutr. Cancer. 1997;29(1):7-12.CrossRefPubMedGoogle Scholar
  5. 5.
    Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev. Res. (Phila). 2014;7(6):574-584.CrossRefGoogle Scholar
  6. 6.
    Ushida J, Sugie S, Kawabata K, Pham QV, Tanaka T, Fujii K, Takeuchi H, Ito Y, Mori H. Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Jpn. J. Cancer Res. 2000;91(9):893-898.CrossRefPubMedGoogle Scholar
  7. 7.
    Wheeler JB, Reed CE. Epidemiology of esophageal cancer. Surg. Clin. North. Am. 2012;92(5):1077-1087.CrossRefPubMedGoogle Scholar
  8. 8.
    Xiang YY, Wang DY, Tanaka M, Igarashi H, Kamo T, Shen Q, Sugimura H, Kino I. Efficient and specific induction of esophageal tumors in rats by precursors of N-nitrososarcosine ethyl ester. Pathol. Int. 1995;45(6):415-421.CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. V. Shubin
    • 1
  • E. A. Lesovaya
    • 2
  • K. I. Kirsanov
    • 2
  • E. E. Antoshina
    • 2
  • L. S. Trukhanova
    • 2
  • T. G. Gorkova
    • 2
  • G. A. Belitsky
    • 2
  • M. G. Yakubovskaya
    • 2
  • I. V. Demidyuk
    • 1
  1. 1.Institute of Molecular Genetics, the Russian Academy of SciencesMoscowRussia
  2. 2.N. N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaMoscowRussia

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