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Combined Action of PGRPs-Hsp70 Cytotoxic Complex with Paclitaxel Improves Outcomes of Melanoma Treatment in Mice

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of PGRPs-Hsp70 cytotoxic complex that is analogous to natural complex secreted by cytotoxic lymphocytes and the antitumor drug paclitaxel on the development of M3 melanoma in DBA mice. Significant inhibition of tumor growth was observed in all experimental groups by days 20 and 35 of observation; paclitaxel monotherapy was less effective than administration of PGRPs-Hsp70 cytotoxic complex and its combination with paclitaxel. Pairwise comparison of Kaplan—Meier curves showed that survival was maximum in the group receiving combined therapy with PGRPs-Hsp70 cytotoxic complex and paclitaxel in comparison with groups receiving monotherapy.

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Authors and Affiliations

  1. V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

    E. A. Dukhanina

  2. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    T. I. Luk’yanova & S. G. Georgieva

  3. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    A. S. Dukhanin

Authors
  1. E. A. Dukhanina
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  2. T. I. Luk’yanova
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  3. A. S. Dukhanin
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  4. S. G. Georgieva
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Corresponding author

Correspondence to A. S. Dukhanin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 11, pp. 614-616, November, 2017

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Dukhanina, E.A., Luk’yanova, T.I., Dukhanin, A.S. et al. Combined Action of PGRPs-Hsp70 Cytotoxic Complex with Paclitaxel Improves Outcomes of Melanoma Treatment in Mice. Bull Exp Biol Med 164, 658–660 (2018). https://doi.org/10.1007/s10517-018-4053-6

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  • DOI: https://doi.org/10.1007/s10517-018-4053-6

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