Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 629–635 | Cite as

GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205

  • K. Yu. Kalitin
  • O. Yu. Grechko
  • A. A. Spasov
  • A. G. Sukhov
  • V. A. Anisimova
  • A. E. Matukhno
Article

The study examined the effect of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α] benzimidazole dihydrochloride (RU-1205) on the latency of seizures provoked by corazol, bicuculline, or picrotoxin. This agent (10 and 20 mg/kg) increased the seizure latency in the experimental models of epileptogenesis. The blockers of GABAA and GABA A -ρ receptors picrotoxin and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid, respectively, were employed to study the effects of RU-1205 on electrical activity of somatosensory cortical neurons and on formation of pathological rhythms in the rat brain. RU-1205 inhibited the focal background rhythm and eliminated the epileptiform activity, which can be mediated by interaction with GABAA receptors.

Key Words

benzimidazoles epilepsy anticonvulsant drugs anticonvulsants GABA receptors 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • K. Yu. Kalitin
    • 1
  • O. Yu. Grechko
    • 1
  • A. A. Spasov
    • 1
    • 2
  • A. G. Sukhov
    • 3
  • V. A. Anisimova
    • 4
  • A. E. Matukhno
    • 3
  1. 1.Department of PharmacologyVolgograd State Medical UniversityVolgogradRussia
  2. 2.Volgograd Medical Science CenterVolgogradRussia
  3. 3.Laboratory of Experimental NeurobiologyD. I. Ivanovsky Academy of Biology and BiotechnologyRostov-on-DonRussia
  4. 4.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia

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