Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 620–623 | Cite as

Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites

  • N. A. Sinyakova
  • E. A. Kulikova
  • N. A. Englevskii
  • A. V. Kulikov

We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the “novel tank” test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.

Key Words

Danio rerio “novel tank” test fluoxetine TC-2153 monoamines 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. A. Sinyakova
    • 1
  • E. A. Kulikova
    • 1
  • N. A. Englevskii
    • 1
  • A. V. Kulikov
    • 1
  1. 1.Federal Research Center Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirskRussia

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