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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 596–600 | Cite as

Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson’s Disease

  • M. N. Karpenko
  • E. Yu. Ilyicheva
  • Z. M. Muruzheva
  • I. V. Milyukhina
  • Yu. A. Orlov
  • L.V. Puchkova
Article

Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson’s disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson’s disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson’s disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson’s disease.

Key Words

Parkinson’s disease copper imbalance ceruloplasmin labile copper atoms of ceruloplasmin Cu/Zn-superoxide dismutase 3 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. N. Karpenko
    • 1
    • 2
    • 3
  • E. Yu. Ilyicheva
    • 1
    • 2
  • Z. M. Muruzheva
    • 1
  • I. V. Milyukhina
    • 1
  • Yu. A. Orlov
    • 2
  • L.V. Puchkova
    • 1
    • 2
    • 3
  1. 1.Institute of Experimental MedicineSt. PetersburgRussia
  2. 2.St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)St. PetersburgRussia
  3. 3.Peter the Great St. Petersburg Polytechnic UniversitySt. PetersburgRussia

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