Posttraumatic stress disorders were induced in Wistar rats by modeling predatory stress. Animals tested in elevated plus-maze demonstrated signs of high anxiety and difficulties in space orientation. Behavioral disorders were paralleled by degenerative changes in hepatocytes. A course of low-dose high-molecular heparin after stress exposure promoted effective adaptation and normalization of behavioral and morphofunctional disorders. Analysis of the results indicated good prospects of heparin as an effective drug under conditions of exposure to extreme factors of psychotraumatic type.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 10, pp. 490-494, October, 2017
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Kondashevskaya, M.V. Experimental Evaluation of the Effects of Low-Dose Heparin on the Behavior and Morphofunctional Status of the Liver in Wistar Rats with Posttraumatic Stress Disorders. Bull Exp Biol Med 164, 488–492 (2018). https://doi.org/10.1007/s10517-018-4018-9
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DOI: https://doi.org/10.1007/s10517-018-4018-9