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Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4+RORγt+ and CD4+FoxP3+T cells and their key products IL-17A and TGF-β was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia

    N. S. Glebezdina, I. V. Nekrasova & E. M. Kuklina

  2. E. A. Wagner Perm State Medical University, Perm, Russia

    A. A. Olina

Authors
  1. N. S. Glebezdina
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  2. A. A. Olina
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  3. I. V. Nekrasova
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  4. E. M. Kuklina
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Corresponding author

Correspondence to N. S. Glebezdina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 10, pp. 459-463, October, 2017

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Glebezdina, N.S., Olina, A.A., Nekrasova, I.V. et al. Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy. Bull Exp Biol Med 164, 462–465 (2018). https://doi.org/10.1007/s10517-018-4013-1

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  • DOI: https://doi.org/10.1007/s10517-018-4013-1

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