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Cellular Composition of the B- and T-Cell-Dependent Areas in the Small Intestine during the Post-Stress Period (Experimental Study)

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

A quantitative study of lymphoid cells in the B- and T-cell-dependent areas of intestinal lymphoid nodules and mesenteric lymph nodes in behaviorally passive and active rats was performed at various periods after acute stress on the model of 1-h immobilization with simultaneous electrocutaneous stimulation. Stress exposure is accompanied by a decrease in the number of lymphoid cells in immunogenic structures of the gastrointestinal tract. Post-stress changes in the cytoarchitectonics of B- and T-cell-dependent areas in mesenteric lymph nodes of animals are less pronounced than in lymphoid nodules. Quantitative changes in lymphoid cells of B-cell-dependent areas in the small intestine of rats are greater than in T-cell-dependent areas. Changes in the cellular composition of immunogenic structures in the digestive system are most significant at the early stages of the post-stress period (1st week). Passive rats are characterized by significant changes in the cytoarchitectonics of B- and Tcell-dependent areas in the small intestine after extreme exposure, which illustrates functional exhaustion of the lymphoid tissue in stress-predisposed specimens.

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Authors and Affiliations

  1. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia

    E. V. Koplik, E. A. Ivanova & S. S. Pertsov

  2. A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation, Moscow, Russia

    S. S. Pertsov

Authors
  1. E. V. Koplik
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  2. E. A. Ivanova
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  3. S. S. Pertsov
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Corresponding author

Correspondence to E. A. Ivanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 10, pp. 404-411, October, 2017

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Koplik, E.V., Ivanova, E.A. & Pertsov, S.S. Cellular Composition of the B- and T-Cell-Dependent Areas in the Small Intestine during the Post-Stress Period (Experimental Study). Bull Exp Biol Med 164, 413–419 (2018). https://doi.org/10.1007/s10517-018-4002-4

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  • DOI: https://doi.org/10.1007/s10517-018-4002-4

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