We performed morphological analysis of the effect of the peptide complex from porcine kidneys on the course of experimental urolithiasis modeled in rats by treatment with 1% ethylene glycol solution (in drinking water) for 6 weeks. The peptide complex obtained by acetic acid extraction was administered in a dose of 15 mg. Administration of the peptide complex to animals with experimental kidney stone disease leads to 100% destruction of large and medium stones to the “dust” granularity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Garicov AU, Bruhanov VM, Zverev YaF, Lampatov VV. Current methods of modeling of oxalate nephrolythiasis. Nefrologiya. 2008;12(4):28-35. Russian.
Jaricov AYu, Zverev YaF, Brukhanov VM, Lampatov VV. The current conceptions about the modulators of the oxalate nephrolythiasis. I. Stimulators of crystallization. Nefrologiya. 2009;13(1):56-72. Russian.
Zharikov AYu, Zverev YaF, Brukhanov VM, Lampatov VV. Mechanism of formation of crystals in oxalate nephrolithiasis. Nefrologiya. 2009;13(4):37-50. Russian.
Zharikov AY, Lampatov VV, Bryukhanov VM, Talalaeva OS, Motin YuG, Pavlyashik GV, Eliseev DV. Experimental aprobation of new biomedicine substence from pork kidneys at the experimental kidney stone disease. Sib. Nauch. Med. Zh. 2015;35(6):45-51. Russian.
Zverev YaF, Zharikov AYu, Brukhanov VM, Lampatov VV. Modulators of oxalate nephrolithiasis. Inhibitors’ crystallization. Nefrologiya. 2010;14(1):29-49. Russian.
Khavinson VK, Shataeva LK, Solov’ev AJ, Ryzhak GA, Kozlov LV. Patent RU No. 2415676. Method of obtaining medication, which has tissue-specific activity, and medication, obtained by claimed method (versions). Bull. No. 10. Published April 10, 2011.
Fedoreyeva LI, Vanyushin BF, Kireev II, Khavinson VKh. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Moscow). 2011;76(11):1210-1219.
Khavinson VKh, Lin’kova NS, Polyakova VO, Durnova AO, Nichik TE, Kvetnoi IM. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull. Exp. Biol. Med. 2014;157(2):261-264.
Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull. Exp. Biol. Med. 2012;153(1):148-151.
Khavinson VKh, Solov’ev AYu, Tarnovskaya SI, Lin’kova NS. Mechanism of biological activity of short peptides: Cell penetration and epigenetic regulation of gene expression. Biol. Bull. Rev. 2013;3(6):451-455.
Allie-Hamdulay S, Rodgers AL. Prophylactic and therapeutic properties of a sodium citrate preparation in the management of calcium oxalate urolithiasis: randomized, placebo-controlled trial. Urol. Res. 2005;33(2):116-124.
Bae EH, Kim IJ, Ma SK, Kim SW. Rosiglitazone prevents the progression of renal injury in DOCA-salt hypertensive rats. Hypertens. Res. 2010;33(3):255-262.
Bashir S, Gilani AH. Antiurolithic effect of berberine is mediated through multiple pathways. Eur. J. Pharmacol. 2011; 651(1-3):168-175.
Ghalayini IF, Al-Ghazo MA, Harfeil MN. Prophylaxis and therapeutic effects of raspberry (Rubus idaeus) on renal stone formation in Balb/c mice. Int. Braz. J. Urol. 2011;37(2):259-266.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 237-240, August, 2017
Rights and permissions
About this article
Cite this article
Zharikov, A.Y., Kiselev, V.I., Saldan, I.P. et al. Morphological Evaluation of the Influence of the Peptide Complex from Tissue of Porcine Kidneys on the Experimental Urolithiasis. Bull Exp Biol Med 164, 207–210 (2017). https://doi.org/10.1007/s10517-017-3959-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3959-8