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Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography

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Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.

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References

  1. Ashmarin IP, Kamenskii AA, Lyapina LA, Myasoedov NF, Samonina GE. Glyprolines as independent regulators and stabilizers of other peptides. Vopr. Biol., Med. Farmatsevt. Khimii. 2002;(1):24-27. Russian.

  2. Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull. Exp. Biol. Med. 2001;131(4):315-317.

    Article  CAS  PubMed  Google Scholar 

  3. Kuznik BI, Khavinson VKh, Tarnovskaya SI, Lin’kova NS. Epigenetic action of regulatory peptides on the cytokine profile and hemostasis system. Vestn. Gematol. 2013;9(4):56-58. Russian.

    Google Scholar 

  4. Lyapina LA, Grigor’eva ME, Obergan TY, Maistrenko ES. The role of the tuftsin and Selank peptides in the regulation of primary and plasma homeostasis. Biol. Bull. 2017;44(2):228-230.

    Article  CAS  Google Scholar 

  5. Lyapina LA, Grigor’eva ME, Obergan TYu, Shubina TA. Theoretical and practical issues of studying the functional state of the blood anticoagulant system. Moscow, 2012. Russian.

  6. Khavinson VKh, Kusnik BI, Tarnovskaya SI, Linkova NS. Pigenetic effect of Lys-Glu and Ala-Glu-Asp-Gly peptides on hemostasis. Tromboz, Gemostaz Reologiya. 2013;(3):26-33. Russian.

  7. Brunini TM, Mendes-Ribeiro AC, Ellory JC, Mann GE. Platelet nitric oxide synthesis in uremia and malnutrition: a role for L-arginine supplementation in vascular protection? Cardiovasc. Res. 2007;73(2):359-367.

    Article  CAS  PubMed  Google Scholar 

  8. Hasan AA, Warnock M, Nieman M, Srikanth S, Mahdi F, Krishnan R, Tulinsky A, Schmaier AH. Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin. Am. J. Physiol. Heart Circ. Physiol. 2003;285(1):H183-H193.

    Article  CAS  PubMed  Google Scholar 

  9. Myasoedova NF, Lyapina LA, Grigorjeva ME, Oberganb TY, Shubina TA, Andreeva LA. Mechanisms for glyproline protection in hypercholesterolemia. Pathophysiology. 2016;23(1):27-33.

    Article  Google Scholar 

  10. Vasilijevic A, Buzadzic B, Korac A, Petrovic V, Jankovic A, Korac B. Beneficial effects of L-arginine nitric oxideproducing pathway in rats treated with alloxan. J. Physiol. 2007;584(Pt 3):921-933.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    E. Ya. Rogozinskaya & M. G. Lyapina

Authors
  1. E. Ya. Rogozinskaya
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  2. M. G. Lyapina
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Correspondence to E. Ya. Rogozinskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 197-200, August, 2017

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Rogozinskaya, E.Y., Lyapina, M.G. Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography. Bull Exp Biol Med 164, 170–172 (2017). https://doi.org/10.1007/s10517-017-3950-4

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  • DOI: https://doi.org/10.1007/s10517-017-3950-4

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