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Melatonin—Aluminum Oxide—Polymethylsiloxane Complex on Apoptosis of Liver Cells in a Model of Obesity and Type 2 Diabetes Mellitus

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We studied the effects of a melatonin—aluminum oxide—polymethylsiloxane complex (complex M) on the expression of apoptosis regulators Bcl-2 and Bad in the liver of homozygous db/db BKS.Cg-Dock7m+/+Leprdb/J mice with obesity and type 2 diabetes. Complex M or placebo was administered daily through the gastric tube during weeks 8-16 of life. In mice with type 2 diabetes mellitus receiving placebo, enhanced immunohistochemical reactions for proapoptotic Bad protein and weak response for anti-apoptotic Bcl-2 protein were observed. Administration of complex M shifted the ratio of apoptosis regulators: the area of Bcl-2 expression significantly increased and against the background of reduced Bad expression area. These findings attest to antiapoptotic effect of complex M in the liver on the model of type 2 diabetes mellitus.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia

    S. V. Michurina, I. Yu. Ischenko, S. A. Arkhipov, V. V. Klimontov, M. A. Cherepanova, M. A. Korolev, L. N. Rachkovskaya & V. I. Konenkov

  2. Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia

    E. L. Zav’yalov

Authors
  1. S. V. Michurina
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  2. I. Yu. Ischenko
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  3. S. A. Arkhipov
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  4. V. V. Klimontov
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  5. M. A. Cherepanova
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  6. M. A. Korolev
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  7. L. N. Rachkovskaya
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  8. E. L. Zav’yalov
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  9. V. I. Konenkov
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Corresponding author

Correspondence to S. V. Michurina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 192-196, August, 2017

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Michurina, S.V., Ischenko, I.Y., Arkhipov, S.A. et al. Melatonin—Aluminum Oxide—Polymethylsiloxane Complex on Apoptosis of Liver Cells in a Model of Obesity and Type 2 Diabetes Mellitus. Bull Exp Biol Med 164, 165–169 (2017). https://doi.org/10.1007/s10517-017-3949-x

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  • DOI: https://doi.org/10.1007/s10517-017-3949-x

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