Regenerative activity of locally applied drugs based on copper nanoparticles was compared on white male rats with an experimental purulent wound infected with clinical polyantibiotic resistant strains of Staphylococcus aureus. The use of a suspension of copper nanoparticles and complex drugs based on chitosan and starch with copper nanoparticles led to a rapid reduction of the wound area and elimination of the wound-contaminating agent, which confirmed high antibacterial and regenerative activity of copper nanoparticles in the composition of the studied drugs.
Similar content being viewed by others
References
Babushkina IV, Mamonova IA, Gladkova EV. Etiological role of chronic osteomyelitis agents and copper nanoparticles influence on clinical Staphylococcus aureus strains. Vestn. Perm. Univer. Ser.: Biol. 2014;(2):52-56. Russian.
Bogdanets LI, Berezina SS, Gelfand EB. Application and effectiveness of antimicrobial agents in the treatment of trophic ulcers in patients with venous insufficiency of the lower limbs. Infektsii Khirurgii. 2007;(2):38-41. Russian.
Deryabin DG, Aleshina ES, Vasilchenko AS, Deryabina TD, Efremova LV, Karimov IF, Korolevskaya LB. Investigation of copper nanoparticles antibacterial mechanisms tested by luminescent Escherichia coli strains. Nanotechnologies in Russia. 2013;8(5-6):402-408.
Kozlov RS. Selection of Resistance Associated with the Use of Antimicrobial Agents: Collateral Damage Concept. Klin. Mikrobiol. Antimikrob. Khimioter. 2010;12(4):284-294. Russian.
Mamonova IA, Babushkina IV, Gladkova EV, Matasov MD, Losev OE, Chebotareva YG, Borodulina YV. Study of physical properties and biological activity of copper nanoparticles. Nanotechnologies in Russia. 2013;8(5-6):303-308.
Díaz-Visurraga J, García A, Cárdenas G. Lethal effect of chitosan-Ag (I) films on Staphylococcus aureus as evaluated by electron microscopy. J. Appl. Microbiol. 2010;108(2):633-646.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 188-191, August, 2017
Rights and permissions
About this article
Cite this article
Babushkina, I.V., Gladkova, E.V., Belova, S.V. et al. Application of Preparations Containing Copper Nanoparticles for the Treatment of Experimental Septic Wounds. Bull Exp Biol Med 164, 162–164 (2017). https://doi.org/10.1007/s10517-017-3948-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3948-y