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Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer

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A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.

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Authors and Affiliations

  1. Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    A. I. Dmitrieva, V. A. Serebryakova, S. S. Rakitin, V. V. Novitskii, K. I. Yankovich & N. V. Sevostyanova

  2. Tomsk Regional Oncology Center, Tomsk, Russia

    A. I. Dmitrieva, V. A. Serebryakova, L. A. Kudyakov & K. I. Yankovich

  3. National Research Tomsk State University, Tomsk, Russia

    V. V. Novitskii & N. V. Sevostyanova

Authors
  1. A. I. Dmitrieva
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  2. V. A. Serebryakova
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  3. S. S. Rakitin
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  4. L. A. Kudyakov
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  5. V. V. Novitskii
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  6. K. I. Yankovich
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  7. N. V. Sevostyanova
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Corresponding author

Correspondence to A. I. Dmitrieva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 7, pp. 110-114, July, 2017

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Dmitrieva, A.I., Serebryakova, V.A., Rakitin, S.S. et al. Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer. Bull Exp Biol Med 164, 95–98 (2017). https://doi.org/10.1007/s10517-017-3932-6

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  • DOI: https://doi.org/10.1007/s10517-017-3932-6

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