Skip to main content
SpringerLink
Log in

Involvement of Microflora Metabolites in Up-Regulation of Electrical Activity in Rat Small Intestine

  • EXPERIMENTAL METHODS FOR CLINICAL PRACTICE
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The study examined implication of tributyrin, a metabolic precursor in small intestinal microflora, in stimulation of electrical activity of duodenum and jejunum. Enteral administration of tributyrin enhanced electrical activity of both examined structures in small intestine with elimination of the rest periods. The stimulatory effect was manifested in a prolongation of the periods of irregular activity. The up-regulating effects of tributyrin on electrical activity in upper segments of small intestine are mediated via the cholecystokinin receptors being also associated with activation of cholinergic and blockade of nitrinergic signal transduction pathways.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ardatskaya MD. Oleic Acid and Inulin in Clinical Practice: Theoretical Aspects and Possibilities of Clinical Application. Moscow, 2014. Russian.

  2. Grider JR, Piland BE. The peristaltic reflex induced by shortchain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Am. J. Physiol. Gastrointest. Liver Physiol. 2007;292(1):G429-G437.

    Article  CAS  PubMed  Google Scholar 

  3. Kamath PS, Phillips SF. Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents. Gut. 1988;29(7):941-948.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP, Neunlist M. Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology. 2010;138(5):1772-1782.

    Article  CAS  PubMed  Google Scholar 

  5. Yajima T. Cotractile effect of short-chain fatty acids on the isolated colon of the rat. J. Physiol. 1985;368:667-678.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health, Moscow, Russia

    N. S. Tropskaya, E. A. Kislyakova & T. S. Popova

Authors
  1. N. S. Tropskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Kislyakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. S. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. S. Tropskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 6, pp. 763-767, June, 2017

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tropskaya, N.S., Kislyakova, E.A. & Popova, T.S. Involvement of Microflora Metabolites in Up-Regulation of Electrical Activity in Rat Small Intestine. Bull Exp Biol Med 163, 796–800 (2017). https://doi.org/10.1007/s10517-017-3906-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3906-8

Key Words

Search

Navigation