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Relationship between Hypoxic Resistance and the Phase of 4-Day Corticosterone Biorhythm in Adult Male Rats

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The relationship between the phase of 4-day serum corticosteroid biorhythm and resistance to acute hypobaric hypoxia was studied in male rats. Single evaluations of hypoxic resistance of Wistar rats during the same time of the day have shown that the lifespan of animals is significantly longer during the 4-day biorhythm acrophase than during the bathyphase. Daily testing for 12 days has detected a 4-day rhythm of hypoxic resistance, synphasic with corticosterone biorhythm, irrespective of the wave-like course of the adaptation process phase from the beginning of daily testing and hypoxic resistance. Experiments on Sprague-Dawley rats have shown that animals highly resistant and medium resistant to hypoxia during the infradian biorhythm acrophase become medium resistant and poorly resistant during the bathyphase. In order to detect the animals with the least hypoxic resistance in the population, the studies should be carried out during the 4-day infradian biorhythm acrophase, while detection of the most resistant animals should be carried out during the bathyphase.

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References

  1. Agadzhanyan NA, Khachatur’yan ML, Panchenko LA. Effect of acute hypoxia on resistance to hypoxia in rats. Bull. Exp. Biol. Med. 1999;127(6):567-570.

    Article  Google Scholar 

  2. Bezrukov VV, Paramononva GI, Rushkevich YuE, Sykalo NV, Timchenko AN, Utko NA, Kholin VA. Some physiological indices and life expectancy in rats with different resistance to hypoxia. Problemy Stareniya Dolgoletiya. 2012;21(4):431-443. Russian.

    CAS  Google Scholar 

  3. Grek OR, Efremov AV, Sharapov VI. Hypobaric hypoxia and metabolism of xenobiotics. Moscow, 2007. Russian.

  4. Deshcherevsky AV, Lukk AA. Searching of the regular components in temporal variations of geophuysical parameters by method of decomposition in non - harmonious components. Vulkanol. Seismol. 2002;(5):65-78. Russian.

  5. Diatroptov ME, Makarova OV, Diatroptova MA. Regularities of infradian rhythms of the esophageal epithelium proliferation activity in Japanese quails (Coturnix Japonica) and male Vistar rats. Geofizich. Protsessy Biosfera. 2014;13(4):82-96. Russian.

    Google Scholar 

  6. Makarova OV, Mikhailova LP, Sidorova EI, Sladkopevtsev AS, Nikonova EV. Comparative structural and functional characteristics of the lungs of Wistar and Sprague-Dawley rats. Klin. Eksp. Morfol. 2012;(4):49-52. Russian.

  7. Meerson FZ. Adaptation Medicine: Concept of Long-Term Adaptation. Moscow, 1993. Russian.

  8. Rafikov AM, Agadzhanyan NA. Daily fluctuations organism resistance to stressful exposures. Patol. Fiziol. Eksp. Ter. 1971;15(1):60-62. Russian.

    CAS  PubMed  Google Scholar 

  9. Jain K, Suryakumar G, Ganju L, Singh SB. Differential hypoxic tolerance is mediated by activation of heat shock response and nitric oxide pathway. Cell Stress Chaperones. 2014;19(6):801-812.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Johnson TS, Rock PB, Fulco CS, Trad LA, Spark RF, Maher JT. Prevention of acute mountain sickness by dexamethasone. N. Engl. J. Med. 1984;310(11):683-686.

    Article  CAS  PubMed  Google Scholar 

  11. Kodama T, Shimizu N, Yoshikawa N, Makino Y, Ouchida R, Okamoto K, Hisada T, Nakamura H, Morimoto C, Tanaka H. Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression. J. Biol. Chem. 2003;278(35):33,384-33,391.

    Article  CAS  Google Scholar 

  12. Masukawa T, Tochino Y. Circadian rhythm in the cerebral resistance to hypoxia in mice. Jpn. J. Pharmacol. 1993;61(3):197-201.

    Article  CAS  PubMed  Google Scholar 

  13. Padhy G, Sethy NK, Ganju L, Bhargava K. Abundance of plasma antioxidant proteins confers tolerance to acute hypobaric hypoxia exposure. High Alt. Med. Biol. 2013;14(3):289-297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000;21(1):55-89.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Human Morphology, Moscow, Russia

    D. Sh. Dzhalilova, A. M. Kosyreva, M. E. Diatroptov & O. V. Makarova

Authors
  1. D. Sh. Dzhalilova
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  2. A. M. Kosyreva
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  3. M. E. Diatroptov
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  4. O. V. Makarova
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Correspondence to D. Sh. Dzhalilova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 5, pp. 647-651, May, 2017

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Dzhalilova, D.S., Kosyreva, A.M., Diatroptov, M.E. et al. Relationship between Hypoxic Resistance and the Phase of 4-Day Corticosterone Biorhythm in Adult Male Rats. Bull Exp Biol Med 163, 687–690 (2017). https://doi.org/10.1007/s10517-017-3879-7

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  • DOI: https://doi.org/10.1007/s10517-017-3879-7

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