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Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions

Bulletin of Experimental Biology and Medicine volume 163, pages 497–499 (2017)Cite this article

Some aspects of resting-state fMRI signal can be the key markers of depression. fMRI was recoded over 4 min in evidently healthy persons (N=21) and in patients with mild depression (N=21). The data were separated into the independent spatial components, and the strength of their association with established brain networks was analyzed. The patients with mild depression were characterized with greater correlations between the components representing the ventral and dorsal subdivisions of default mode network (DMN), whereas correlations between the components relating to cerebellum and to the left hemisphere language system were less pronounced. The data revealed a significant role of DMN in the development of affective abnormalities and importance of its functional state as a probable marker of mild depression.

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Affiliations

  1. Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia

    M. E. Mel’nikov, D. D. Bezmaternykh, L. I. Kozlova, M. B. Shtark & O. S. Shubina

  2. International Tomography Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    E. D. Petrovskii & A. A. Savelov

  3. Novosibirsk National State Research University, Novosibirsk, Russia

    M. E. Mel’nikov, D. D. Bezmaternykh, L. I. Kozlova & M. B. Shtark

  4. International Institute of Psychology and Psychotherapy, Novosibirsk, Russia

    K. A. Natarova

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  1. M. E. Mel’nikov
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  2. D. D. Bezmaternykh
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  3. E. D. Petrovskii
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  4. L. I. Kozlova
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  5. M. B. Shtark
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  6. A. A. Savelov
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  7. O. S. Shubina
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  8. K. A. Natarova
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Correspondence to M. E. Mel’nikov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 499-502, April, 2017

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Mel’nikov, M.E., Bezmaternykh, D.D., Petrovskii, E.D. et al. Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions. Bull Exp Biol Med 163, 497–499 (2017). https://doi.org/10.1007/s10517-017-3837-4

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  • DOI: https://doi.org/10.1007/s10517-017-3837-4

Key Words

  • depression
  • default mode network
  • analysis of independent components
  • resting-state fMRI