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Assessment of Erythroid and Granulocytic Hematopoietic Lineages in Patients with Non-Small-Cell Lung Carcinoma

  • ONCOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

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The toxic effects of combined cisplatin/docetaxel therapy cycles on erythroid and granulocytic hematopoietic lineages as well as their intercycle recovery were examined in patients with stage III-IV non-small-cell lung carcinoma. Responsiveness of the blood system to this therapy remained at a high level. Combined therapy pronouncedly activated the key elements of the erythroid and granulocytic hematopoietic lineages leading to accumulation of immature and mature myelokaryocytes in the bone marrow, enlargement of the medullary pool of mature neutrophils, and increase in the count of medullary erythroid and granulocytic precursor cells under conditions of their accelerated maturation.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

    T. Yu. Polyakova, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, E. V. Simanina, A. M. Dygai & G. N. Zyuz’kov

  2. Research Institute of Oncology, Tomsk National Research Medical Center, Tomsk, Russia

    V. E. Goldberg, N. O. Popova, V. V. Vysotskaya, E. I. Simolina, Yu. V. Belevich, T. P. Tuzikova & A. V. Goldberg

  3. National Research Tomsk State University, Tomsk, Russia

    T. Yu. Polyakova

Authors
  1. V. E. Goldberg
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  2. T. Yu. Polyakova
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  3. N. O. Popova
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  4. V. V. Vysotskaya
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  5. E. I. Simolina
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  6. Yu. V. Belevich
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  7. T. P. Tuzikova
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  8. A. V. Goldberg
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  9. V. V. Zhdanov
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  10. L. A. Miroshnichenko
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  11. E. V. Udut
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  12. E. V. Simanina
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  13. A. M. Dygai
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  14. G. N. Zyuz’kov
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 466-472, April 2017

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Goldberg, V.E., Polyakova, T.Y., Popova, N.O. et al. Assessment of Erythroid and Granulocytic Hematopoietic Lineages in Patients with Non-Small-Cell Lung Carcinoma. Bull Exp Biol Med 163, 469–474 (2017). https://doi.org/10.1007/s10517-017-3830-y

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  • DOI: https://doi.org/10.1007/s10517-017-3830-y

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